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SOIL2GUT

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Impact of soil microbiodiversity on the development of wild mammal gut biota and...

Impact of soil microbiodiversity on the development of wild mammal gut biota and immune function The biodiversity hypothesis asserts there is a link between the diversity of environmental and host-associated microbes and ‘civilization diseases', such as asthma and allergies, the result of immune dysfunction and chronic inflam... ver más

31/10/2025

FEM

Presupuesto desconocido

Líder del proyecto

FONDAZIONE EDMUND MACH No se ha especificado una descripción o un objeto social para esta compañía.

TRL 4-5

Fecha límite participación Sin fecha límite de participación.

Financiación concedida El organismo HORIZON EUROPE notifico la concesión del proyecto el día 2023-11-01

HORIZON-MSCA-2022-PF-01-01: MSCA Postdoctoral Fellowships 2022 ExpectedOutcome:

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Duración del proyecto: 23 meses Fecha Inicio: 2023-11-01
Fecha Fin: 2025-10-31

Líder del proyecto

FONDAZIONE EDMUND MACH No se ha especificado una descripción o un objeto social para esta compañía.

TRL 4-5

Fecha límite de participación Sin fecha límite de participación.

Descripción del proyecto The biodiversity hypothesis asserts there is a link between the diversity of environmental and host-associated microbes and ‘civilization diseases', such as asthma and allergies, the result of immune dysfunction and chronic inflammation. Using a well-studied rodent model, the bank vole, SOIL2GUT will test for the first time whether exposure to natural communities of soil microbes during development can improve individual health by promoting microbiota function at the host-microbiota interface (ileum and colon mucous layers) and reduce the risk of immune-related diseases. SOIL2GUT will take advantage of tissue samples generated by an ongoing intervention experiment, promoting the 3Rs policy, but also providing a unique opportunity for ‘omics integration (metataxonomics + MTX). Innovatively, this project will focus on the function of gut flora (not merely taxonomical characterization), in both bacteria and fungi (the latter is particularly unusual), using recent developments in metatranscriptonomics (MTX) to explore functional activity, and combining metadata and metatranscriptomes in statistical models to identify critical factors determining health. Since 68% of the human population will be urbanized by 2050, SOIL2GUT will contribute significantly to the WHO OneHealth framework. This project will also provide data that can be used to plan urban greenspaces, enhance rewilding interventions and improve domestic and zoo animal wellbeing. The researcher will build on his previous experiences and solid publications as a PhD/postdoc, receiving advanced personalized training in bioinformatics and soft skills, including writing grant applications for expanding to other tissues (lung, skin), and rendering him highly employable. In exchange, the researcher will bring methods for measuring individual health and immune gene expression to the hosting lab, among others. A synergy of expertise in microbiota research is envisaged, leading to future collaborative endeavors.

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