FRANKIE
Financiado
Impact of exposure to chemicals to the onset and progression of Lewy Body Dement...
With aging, the incidence of neurodegenerative diseases is increasing. Clinical manifestations of neurodegenerative disease often result in dementia, a group of symptoms including loss of memory and impaired cognitive functions th...
With aging, the incidence of neurodegenerative diseases is increasing. Clinical manifestations of neurodegenerative disease often result in dementia, a group of symptoms including loss of memory and impaired cognitive functions that have serious consequences for the wellbeing of aging individuals and society. Dementia is a syndrome of many diseases, including Lewy body dementia (LBD).
Whilst the genetic factors contributing to the development of LBD have been investigated, links between exposure to chemicals and LBD have not been sufficiently studied. The FRANKIE project aims to comprehensively investigate the chemical exposome of patients with LBD and elucidate underlying mechanisms of exposure-related neurotoxicity. Blood-based chemical exposure agents and metabolites of LBD patients will be measured via a unique dual liquid chromatography coupled to high-resolution mass spectrometry platform. Advanced statistical and data mining methods will be employed to associate chemical exposures with dysregulated metabolic pathways to identify biomarkers of effect. Furthermore, by comparison of metabolic profiles of healthy people, people with early LBD and LBD patients, novel prodromal and clinical blood biomarkers will be identified.
The proposed interdisciplinary, data-driven study is a big step towards understanding the influence of everyday chemical exposure on the onset and progression of neurodegenerative disease. The FRANKIE project will produce mechanistic insights of chemical exposure-related neurotoxicity, providing the opportunity to identify prevention measures and potentially reduce the incidence of neurodegenerative diseases to improve the quality of life of the elderly and aging populations and contribute towards a healthier society.
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Duración del proyecto: 25 meses
Fecha Inicio: 2023-05-09
Fecha Fin: 2025-06-30
Fecha Fin: 2025-06-30
Línea de financiación: concedida
El organismo HORIZON EUROPE notifico la concesión del proyecto el día 2023-05-09
Línea de financiación objetivo
El proyecto se financió a través de la siguiente ayuda:
Presupuesto
El presupuesto total del proyecto asciende a
150K€
Líder del proyecto
Masarykova univerzita
No se ha especificado una descripción o un objeto social para esta compañía.
Perfil tecnológico
TRL
4-5
Perfil tecnológico
TRL
4-5