Hola,
¿eres nuevo aquí?

Regístrate gratis y conecta tu empresa con financiación pública, partners y proyectos.

Tengo cuenta

Regístrate

Ver video

SHAPINCELLFATE

Financiado

Impact of cell shapes on cell behaviour and fate

Cells are often depicted as irregular spherical objects - the shape they adopt in suspension. However, the packed environment of tissues alters this simple shape, causing large cell deformations. This occurs during normal tissue g... ver más

31/03/2029

CNRS

11M€

Presupuesto del proyecto: 11M€

Líder del proyecto

CENTRE NATIONAL DE LA RECHERCHE SCIENTIFIQUE... No se ha especificado una descripción o un objeto social para esta compañía.

TRL 4-5

Ver 5 Participantes

Financiación concedida El organismo HORIZON EUROPE notifico la concesión del proyecto el día 2023-03-06

ERC-2022-SyG: ERC Synergy Grants Objective:Objectives

I+D

Cerrada hace 3 años

0% 100% 100%

Información adicional privada

No hay información privada compartida para este proyecto. Habla con el coordinador.

5 Participantes

CNRS

5.61M€ | Lider

ISTITUTO EUROPEO DI ONCOLOGI...

321.38K€ | Participante

INSERM

2.54M€ | Participante

UMIL

2.69M€ | Participante

Conecta tu I+D

¿Tienes un proyecto y buscas un partner? Gracias a nuestro motor inteligente podemos recomendarte los mejores socios y ponerte en contacto con ellos. Te lo explicamos en este video

Proyectos interesantes

PID2019-103900GB-I00 ANALISIS REALISTA DE LA AUTO-ORGANIZACION EPITELIAL EN TRES... 218K€ Cerrado

PID2020-116273GB-I00 BIOMECANICA DE LA MORFOGENESIS: DE LA SALUD A LA ENFERMEDAD 206K€ Cerrado

UnderPressure Elucidating the phenotypic convergence of proliferation redu... 1M€ Cerrado

TEC2015-73064-EXP DESCIFRANDO LA ESTRUCTURA Y LA FUNCION DE LAS PROTUSIONES CE... 48K€ Cerrado

RYC-2013-14308 Cellular Migration and Tumourigenesis 309K€ Cerrado

PID2021-128674OB-I00 RESTABLECIENDO LA MECANOBIOLOGIA FISIOLOGICA EN CELULAS CULT... 157K€ Cerrado

Duración del proyecto: 72 meses Fecha Inicio: 2023-03-06
Fecha Fin: 2029-03-31

Líder del proyecto

CENTRE NATIONAL DE LA RECHERCHE SCIENTIFIQUE... No se ha especificado una descripción o un objeto social para esta compañía.

TRL 4-5

Presupuesto del proyecto 11M€

Descripción del proyecto Cells are often depicted as irregular spherical objects - the shape they adopt in suspension. However, the packed environment of tissues alters this simple shape, causing large cell deformations. This occurs during normal tissue growth and is even more pronounced upon tissue overgrowth, as in the case of solid tumors. Cell shape changes frequently occur in migratory cells, such as immune cells that patrol the organism within interstitial tissues, and cancer metastases that escape from the primary tumor to invade healthy tissues. In all cases, cells adapt and survive even to very large deformations. The mechanisms underlying such response and the long-term consequences that repeated cell shape changes have on physiology and pathology remain largely unknown. We have observed that changes in the shape of cells and organelle(s) induce reversible and irreversible modifications in their behaviour and function(s). We hypothesize that cells use such mechanisms to integrate the successive deformations of distinct amplitudes and durations that they experience during their lifetime. This implies the existence of shape-induced memory effects that not only encode the geometrical and mechanical history of the cell but also dictate its fate. Here, we propose to tackle the molecular mechanisms and physical principles accounting for shape-induced memory effects and to evaluate their impact on immunity and cancer. We will focus on two cell types that undergo large shape changes in vivo, and communicate to establish cancer immunity: (1) dendritic cells, which initiate adaptive immune responses, and (2) cancer cells derived from mammary epithelia. Our project will reveal whether boundary conditions imposed by physical confinement are overarching determinants of cellular behaviours at different spatial and temporal scales, and may further establish novel clinical paths for a holistic understanding of early malignancies and their recognition by the immune system.

Conecta tu I+D

Entra hoy

¿Olvidé mi contraseña?

Financiación

Empresas

CTIs/Universidades

Proyectos

Investigadores