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I-MUSCLE

Financiado

Cerrado

Imaging of MUscle Shape Changes during eLEctrically-stimulated contractions

When we move, our muscles contract, and by doing so change shape. While such shape changes are obvious and are required for a muscle to increase its force, we know little about its functional role in force production. Muscle force... ver más

31/08/2024

UANTWERPEN

176K€

Presupuesto del proyecto: 176K€

Líder del proyecto

UNIVERSITEIT ANTWERPEN No se ha especificado una descripción o un objeto social para esta compañía.

TRL 4-5

Fecha límite participación Sin fecha límite de participación.

Financiación concedida El organismo HORIZON EUROPE notifico la concesión del proyecto el día 2024-08-31

HORIZON-MSCA-2021-PF-01-01: MSCA Postdoctoral Fellowships 2021 ExpectedOutcome:

I+D

Cerrada hace 3 años

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1 Participantes

UANTWERPEN

175.92K€ | Lider

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Duración del proyecto: 27 meses Fecha Inicio: 2022-05-29
Fecha Fin: 2024-08-31

Líder del proyecto

UNIVERSITEIT ANTWERPEN No se ha especificado una descripción o un objeto social para esta compañía.

TRL 4-5

Presupuesto del proyecto 176K€

Fecha límite de participación Sin fecha límite de participación.

Descripción del proyecto When we move, our muscles contract, and by doing so change shape. While such shape changes are obvious and are required for a muscle to increase its force, we know little about its functional role in force production. Muscle force is one of the most important parameters in the science of movement, yet it remains impossible to measure in humans. Understanding the precise link between muscle shape changes and muscle forces and advancing methodologies for measuring such muscle shape changes can thus have an important fundamental and ultimately also clinical scientific impact. In I-MUSCLE, I propose to first advance innovative techniques for measuring whole muscle shape changes during muscle contractions, and secondly, to use these advancements to answer key questions about 3D muscle shape changes and its role in force production. I will take an in situ approach to study the calf muscle of guinea fowl (Numida meleagrisis L.). I will stimulate the muscle to induce steady-state contractions at different muscle-tendon unit lengths, at different activation levels, and during concentric and eccentric dynamic contractions. I will measure the muscle shape changes by using state-of-the-art imaging modalities, i.e. ultrafast computed tomography (< 2s) and high-speed stereo (3D) X-ray videography (up to 750 Hz), while also recording muscle forces. The shape changes will be assessed (i) when the muscle is activated globally and (ii) when the muscle is activated locally in specific parts of the muscle. The latter is relevant given that we often activate only parts of our muscles, for example during walking or when using electrical muscle stimulation for rehabilitation purposes. Gaining a better understanding of how muscles change shape under realistic conditions and how it is linked to muscle force is critical for treatment of neurological disorders affecting muscle contraction, patient rehabilitation following injury or surgery, and development of bio-inspired robotics.

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