Hola,
¿eres nuevo aquí?

Regístrate gratis y conecta tu empresa con financiación pública, partners y proyectos.

Tengo cuenta

Regístrate

Ver video

LIVER IVM

Financiado

Cerrado

Imaging liver immunopathology by intravital microscopy

The objective of this proposal is to take advantage of recently developed technological progresses in the field of live imaging to elucidate the pathogenesis of hepatitis B virus (HBV) infection. CD8 T cells play a major part in t... ver más

Fecha desconocida

HSR

100K€

Presupuesto del proyecto: 100K€

Líder del proyecto

FONDAZIONE CENTRO SAN RAFFAELE DEL MONTE TABO... No se ha especificado una descripción o un objeto social para esta compañía.

TRL 4-5

Fecha límite participación Sin fecha límite de participación.

Financiación concedida El organismo FP7 notifico la concesión del proyecto No tenemos la información de la convocatoria

0% 100% 100%

Información adicional privada

No hay información privada compartida para este proyecto. Habla con el coordinador.

1 Participantes

HSR

0.00€ | Lider

Conecta tu I+D

¿Tienes un proyecto y buscas un partner? Gracias a nuestro motor inteligente podemos recomendarte los mejores socios y ponerte en contacto con ellos. Te lo explicamos en este video

Proyectos interesantes

LIVER IVM AND HBV Imaging liver immunopathology by intravital microscopy IVM... 2M€ Cerrado

Liver IVM Visualizing liver immunopathology progression during hepatit... 180K€ Cerrado

FATE Functional Biology of Hepatic CD8 T cells 2M€ Cerrado

EUCLIDEAN Acquired adaptive immune cell dysfunction and restoration in... 3M€ Cerrado

MOD-REG Modulating Tregs in liver disease for therapeutic benefit 189K€ Cerrado

IVM-VIRUS-NAB In vivo dynamics of antibody responses to lymph borne viruse... 2M€ Cerrado

Líder del proyecto

FONDAZIONE CENTRO SAN RAFFAELE DEL MONTE TABO... No se ha especificado una descripción o un objeto social para esta compañía.

TRL 4-5

Presupuesto del proyecto 100K€

Fecha límite de participación Sin fecha límite de participación.

Descripción del proyecto The objective of this proposal is to take advantage of recently developed technological progresses in the field of live imaging to elucidate the pathogenesis of hepatitis B virus (HBV) infection. CD8 T cells play a major part in the development of liver disease and the resolution of HBV infection. A number of important issues pertaining to HBV pathogenesis remain unresolved and they include the way in which CD8 T cells traffic and recognize antigen within the liver and the way in which the diseased liver influences these processes. Our rationale is based on the notion that - at last - we can address these and other related issues experimentally. Single- and two-photon intravital microscopy will be carried out in un-inflamed or fibrotic/cirrhotic livers from mouse models that include transgenic mice that express all of the viral polypeptides and replicate HBV in the hepatocyte and normal mice infected with HBV-replicating, hepatotropic, fluorescent adenoviruses. The spatial and temporal constraints of naïve or effector HBV-specific CD8 T cells recognizing viral antigens and interacting intrahepatically with platelets, endothelial cells or Kupffer cells will be visualized thanks to experimental systems created specifically for this purpose. These studies will shed new light on previously unknown aspects of HBV pathogenesis, paving the road to new immunotherapeutic strategies aimed at terminating chronic HBV infection. Results from this proposal may also have far-reaching implications, not only in related liver infections (i.e. hepatitis C virus), but also in other T cell-mediated pathological conditions of the liver such as autoimmunity, graft rejection or cancer.

Conecta tu I+D

Entra hoy

¿Olvidé mi contraseña?

Financiación

Empresas

CTIs/Universidades

Proyectos

Investigadores