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Imaging Brain Circuits to Decode Brain Computations Multimodal Multiscale Imagi...

Imaging Brain Circuits to Decode Brain Computations Multimodal Multiscale Imaging of Cortical Microcircuits to Model Predictive Coding in Human Vision The human brain is one of the largest and most complex biological networks known to exist. The architecture of its circuits, and therefore the computational basis of human cognition, remains largely unknown. The central aim of thi... ver más

30/11/2020

UNIVERSITEIT MAAST...

2M€

Presupuesto del proyecto: 2M€

Líder del proyecto

UNIVERSITEIT MAASTRICHT No se ha especificado una descripción o un objeto social para esta compañía.

TRL 4-5

Ver 2 Participantes

Financiación concedida El organismo H2020 notifico la concesión del proyecto el día 2020-11-30

ERC-StG-2014: ERC Starting Grant

I+D

Cerrada hace 10 años

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2 Participantes

UNIVERSITEIT MAASTRICHT

1.50M€ | Lider

FORES DISEÑO

735.26K€ | Participante

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Duración del proyecto: 66 meses Fecha Inicio: 2015-05-11
Fecha Fin: 2020-11-30

Líder del proyecto

UNIVERSITEIT MAASTRICHT No se ha especificado una descripción o un objeto social para esta compañía.

TRL 4-5

Presupuesto del proyecto 2M€

Descripción del proyecto The human brain is one of the largest and most complex biological networks known to exist. The architecture of its circuits, and therefore the computational basis of human cognition, remains largely unknown. The central aim of this proposal is to image human cortical connectivity at multiple spatial scales in order to understand human cortical computations. Whereas canonical cortical microcircuits are an established theory of the repeating structure of the neocortex’s circuits, predictive coding provides a prominent proposal of what these circuits compute. This leads to the core hypothesis of this proposal: the variations in predictive coding computations performed by human cortical microcircuits in different visual areas are grounded in variations in their microcircuit connectivity. As a central case-study, this proposal investigates human visual apparent motion perception in V1/2/3 and V5/MT+. The proposed research program is organized in two workpackages (WP I and II). WP I has the aim of imaging the multiscale connections of human neocortical microcircuits. The projects in WP I focus on structure and move from the mesoscale down to the microscale. WP II has the aim of modelling how microcircuits support predictive coding computations. The projects in WP II focus on function and move from the microscale back up to the mesoscale. Structural and functional assessment of microcircuitry in the human brain only recently became possible with the development of magnetic resonance imaging (MRI) at ultra-high field-strengths (UHF) of 7T and above. UHF diffusion MRI, combined with light microscopy, is used to image circuit structure in WP I. UHF functional MRI is used for computational modelling of computations in WP II. Successful completion of the planned research will significantly advance our understanding of the computations in cortical microcircuits, deliver important new human connectomic reference data, and improve generative models of human cortical processing.

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