Hola,
¿eres nuevo aquí?

Regístrate gratis y conecta tu empresa con financiación pública, partners y proyectos.

Tengo cuenta

Regístrate

Ver video

FASTer

Financiado

Identifying the Fast-acting Antidepressant Signatures of Treatment Response with...

Identifying the Fast-acting Antidepressant Signatures of Treatment Response with psychedelic compounds using a novel behavioral tracking system and single-cell resolution Mental health disorders affect 84 million people across Europe and are associated with an economic burden of €600 billion/year. New evidence from clinical trials suggests that a single treatment with psychedelic compounds, such as... ver más

31/12/2028

2M€

Presupuesto del proyecto: 2M€

Líder del proyecto

KAROLINSKA INSTITUTET No se ha especificado una descripción o un objeto social para esta compañía.

TRL 4-5

Financiación concedida El organismo HORIZON EUROPE notifico la concesión del proyecto el día 2023-11-17

ERC-2023-STG: ERC STARTING GRANTS Scope:Objectives

I+D

Cerrada hace 2 años

0% 100% 100%

Información adicional privada

No hay información privada compartida para este proyecto. Habla con el coordinador.

1 Participantes

1.50M€ | Lider

Conecta tu I+D

¿Tienes un proyecto y buscas un partner? Gracias a nuestro motor inteligente podemos recomendarte los mejores socios y ponerte en contacto con ellos. Te lo explicamos en este video

Proyectos interesantes

RYC-2011-08391 Proteomic and Bioinformatic Studies of Synaptic Function in... 184K€ Cerrado

PID2021-125448OB-I00 PSICODELICOS SEROTONERGICOS Y PLASTICIDAD NEURONAL: DESVELAN... 198K€ Cerrado

TRANS-PSYCH Transcriptional Regulation Assessed in Neuronal Subtypes in... 1M€ Cerrado

DREAM The pharmaco-microbiomics of depression 217K€ Cerrado

REDIRECT Resolving sEx DIffeREnces in proCessing sensory informaTion 2M€ Cerrado

BETTERCHOICES Understanding and improving choices: investigating the role... 217K€ Cerrado

Duración del proyecto: 61 meses Fecha Inicio: 2023-11-17
Fecha Fin: 2028-12-31

Líder del proyecto

KAROLINSKA INSTITUTET No se ha especificado una descripción o un objeto social para esta compañía.

TRL 4-5

Presupuesto del proyecto 2M€

Descripción del proyecto Mental health disorders affect 84 million people across Europe and are associated with an economic burden of €600 billion/year. New evidence from clinical trials suggests that a single treatment with psychedelic compounds, such as psilocybin, can produce a fast (hours) and sustained (months) antidepressant (AD) response. However, many questions still remain about its mechanism of action, due to methodological challenges such as lack of knowledge of the brain cells and circuits where AD effects are taking place and limitations of the behavioral tests used to examine AD activity in rodents. Combining molecular, behavioral and advanced computational tools, FASTer will establish a groundbreaking and automatic behavioral tracking system to deconstruct the behavioral language associated with treatment response. In addition, FASTer will identify the brain cells and circuits responsible for the fast-acting and sustained AD effects of psilocybin. This is a move away from the traditional assessment of single behavioral readouts to unconventional group behaviors and endophenotypes in a translationally-relevant context that will cause a paradigm shift and revolutionize the field of behavioral phenotyping. Thanks to my unique know-how in bridging human and pre-clinical psychiatry, and to go beyond the state-of-the-art, I will combine activity-dependent labelling techniques and single-cell methods to identify the genes and brain circuits engaged during psilocybin treatment. To address the multidimensional nature of psychiatric disorders, I will manipulate gene networks related to the AD effects of psilocybin. The ambitious and innovative studies proposed here have the potential to change our understanding of psychiatric disorders, and transform the field of behavioral neuroscience. Ultimately, FASTer holds tremendous promise for translatability of preclinical findings and impacting the development of fast-acting and efficacious treatments for psychiatric disorders.

Conecta tu I+D

Entra hoy

¿Olvidé mi contraseña?

Financiación

Empresas

CTIs/Universidades

Proyectos

Investigadores