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ICECOUP

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ICE coupling protein inhibitors

Antibiotic resistance (AR) is one of the greatest threats to human health. The global overuse of antibiotics has resulted in the proliferation and dissemination of antibiotic resistant bacteria harboring a multitude of antibiotic... see more

14/03/2026

UPV

165K€

Project Budget: 165K€

Project leader

UNIVERSIDAD DEL PAIS VASCO/EUSKAL HERRIKO UNI... No se ha especificado una descripción o un objeto social para esta compañía.

total researchers 44

PARTICIPATION DEPralty Sin fecha límite de participación.

Financing granted El organismo HORIZON EUROPE notifico la concesión del proyecto The day 2023-04-06

HORIZON-MSCA-2022-PF-01-01: MSCA Postdoctoral Fellowships 2022 Expected Outcome:

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characteristics of the participant

Este proyecto no cuenta con búsquedas de partenariado abiertas en este momento.

Private Information

No hay información privada compartida para este proyecto. Habla con el coordinador.

1 Participantes

UPV

165.31K€ | Leader

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Project duration: 35 months Date Start: 2023-04-06
End date: 2026-03-14

Project leader

UNIVERSIDAD DEL PAIS VASCO/EUSKAL HERRIKO UNI... No se ha especificado una descripción o un objeto social para esta compañía.

total researchers 44

Project Budget 165K€

participation deadline Sin fecha límite de participación.

Project description Antibiotic resistance (AR) is one of the greatest threats to human health. The global overuse of antibiotics has resulted in the proliferation and dissemination of antibiotic resistant bacteria harboring a multitude of antibiotic resistance genes that can be mobilized by different horizontal gene transfer processes such as conjugation. Integrative Conjugative Elements (ICEs) are mobile genetic elements which are typically found integrated in the bacterial chromosome and encode the machinery for their conjugation. The so-called coupling proteins have a critical role in the conjugation process. ICECOUP is focused on the molecular and functional characterization of a critical component for ICE transmission, the coupling protein, with the ultimate goal of finding ICE conjugation inhibitors to block or, at least, minimize the AR spread. To date, ICE coupling proteins have received little attention despite their importance in the transfer mechanism. The supervision of Dr. Itziar Alkorta at the University of Basque Country(UPV/EHU) is a key element to guarantee the success of this project. ICECOUP will generate extensive and innovative scientific outputs that in the long run will have a societal impact, enhancing the catalogue of weapons to combat antibiotic resistance. The multidisciplinary approach of ICECOUP will allow me the reinforce my scientific knowledge and soft skills, while I acquire outreach and project management capacities. Undoubtedly, should this project be funded, it will strengthen my prospects to forge a stable career as an independent researcher able to secure funding.

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