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InterLynk

Financiado

Cerrado

Human Platelet Lysates based Scaffolds for Interfacial Multi tissue Repair

InterLynk aims to develop multi-tissue 3D patient-specific scaffolds by providing a portfolio of highly compatible and biofunctional composite inks and biomaterials, and streamlining their co-processing using an upgraded AM equipm... ver más

31/01/2025

UAveiro

6M€

Presupuesto del proyecto: 6M€

Líder del proyecto

UNIVERSIDADE DE AVEIRO No se ha especificado una descripción o un objeto social para esta compañía.

TRL 4-5

Fecha límite participación Sin fecha límite de participación.

Ver 8 Participantes

Financiación concedida El organismo H2020 notifico la concesión del proyecto el día 2025-01-31

NMBP-21-2020: Biological scaffolds for tissue reg... Specific Challenge:The increasing availability of novel biomaterials with tissue regeneration proper...

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Este proyecto no cuenta con búsquedas de partenariado abiertas en este momento.

Información adicional privada

No hay información privada compartida para este proyecto. Habla con el coordinador.

8 Participantes

UAveiro

1.63M€ | Lider

Promoscience

180.00K€ | Participante

Env

400.00K€ | Participante

METATISSUE

799.84K€ | Participante

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Duración del proyecto: 49 meses Fecha Inicio: 2020-12-02
Fecha Fin: 2025-01-31

Líder del proyecto

UNIVERSIDADE DE AVEIRO No se ha especificado una descripción o un objeto social para esta compañía.

TRL 4-5

Presupuesto del proyecto 6M€

Fecha límite de participación Sin fecha límite de participación.

Descripción del proyecto InterLynk aims to develop multi-tissue 3D patient-specific scaffolds by providing a portfolio of highly compatible and biofunctional composite inks and biomaterials, and streamlining their co-processing using an upgraded AM equipment. Unprecedented biofunctionality in the synthetic reconstruction of complex interfacial tissues is expected to be obtained. A double network photocrosslinkable biomaterial system based on human plasma-derived Platelet Lysates (PL) will be used as base matrix. The PL-based hydrogels will be further combined with mechanically reinforcing biomaterials, namely CaP-based bioceramics and PCL-LA polymers, to produce bone-like and fibrous structures, respectively, and will be able to be blended with natural drug carriers (flavonoid-loaded nanomicelles). Compositional and structural variations will be enabled by combining photo-assisted printing and MEW/ESP in a single-step hybrid AM process. New computational tools will support the mechanobiological optimization of all biomaterials and final parts, as well as the AM process design. Superior biofunctionality of the InterLynk’ scaffolds will be validated in an highly complex multi-tissue interfacial biosystem, the temporomandibular joint. InterLynk will implement comprehensive strategies to engage key groups of stakeholders (clinical, engineering, regulatory and market-related) in the development of biological scaffolds, establishing a truly multidisciplinary co-creation process. These scaffolds are expected to have no counterpart in both fabrication and multi-tissue regeneration, avoiding time-consuming and costly procedures in both dimensions. This will increase current AM (bio)fabrication capabilities and application range, widely extending its use. Their high flexibility and unique performance will considerably reduce immune rejection, risk of contamination and, inherently, rehabilitation time of multi-tissue injuries resulting in increasing wellbeing and healthcare costs reduction.

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