Innovating Works

HRMEG

Financiado
HRMEG High resolution magnetoencephalography Towards non invasive corticograph...
To date, neuroimaging has provided a wealth of information on how the human brain works in health and disease. With functional magnetic resonance imaging (fMRI), we can obtain spatially precise information about long-lasting brain... To date, neuroimaging has provided a wealth of information on how the human brain works in health and disease. With functional magnetic resonance imaging (fMRI), we can obtain spatially precise information about long-lasting brain activations whereas electro- and magnetoencephalography (EEG/MEG) can track transient cortical responses at millisecond resolution. However, none of these methods excel in time-resolved detection of sustained cortical activations, which are typically reflected as bursts of gamma-range (30–150 Hz) oscillations, frequently present in invasive recordings in patients. Although we have recently demonstrated that in exceptional situations MEG can detect even single gamma responses, their signal-to-noise ratio is usually prohibitively low, largely due to the substantial distance (4–5 cm) between cortex and sensors. Here, I propose to exploit recent advances in a novel magnetic sensor technology—atomic magnetometry—to construct a new kind of MEG system that allows capturing cerebral magnetic fields within millimetres from the scalp. Our simulations show that this proximity leads up to a 5-fold increase in the signal amplitude and an order-of-magnitude improvement of spatial resolution compared to conventional MEG. Therefore, a high-resolution MEG (HRMEG) system based on atomic magnetometers should enable non-invasive recordings of cortical activity at unprecedented sensitivity and detail level, which I propose to capitalize on by characterizing cortical responses, particularly gamma oscillations, during complex cognitive tasks. Additionally, since atomic magnetometers can recover within milliseconds from fields of several tesla, I also propose to combine transcranial magnetic stimulation (TMS) with MEG, leveraging the reciprocity of TMS and MEG and thus allowing better-than-ever characterization of TMS-evoked responses. This proposal comprises the research towards a HRMEG system and its application to study the working human brain in a new way. ver más
31/08/2022
AALTO
1M€
Perfil tecnológico estimado
Duración del proyecto: 73 meses Fecha Inicio: 2016-07-08
Fecha Fin: 2022-08-31

Línea de financiación: concedida

El organismo H2020 notifico la concesión del proyecto el día 2022-08-31
Línea de financiación objetivo El proyecto se financió a través de la siguiente ayuda:
ERC-StG-2015: ERC Starting Grant
Cerrada hace 9 años
Presupuesto El presupuesto total del proyecto asciende a 1M€
Líder del proyecto
AALTO KORKEAKOULUSAATIO SR No se ha especificado una descripción o un objeto social para esta compañía.
Perfil tecnológico TRL 4-5