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Body2Mind

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How does a need turn to a want using Drosophila melanogaster to identify how t...

How does a need turn to a want using Drosophila melanogaster to identify how the gut brain axis mediates protein appetite "The quality and quantity of consumed nutrients, including proteins, has a significant impact on health and lifespan across phyla. Essential amino acids (eAAs) are an extreme case, as many animals, including humans and Drosophila,... ver más

27/04/2024

FUNDACAO CHAMPALIM...

160K€

Presupuesto del proyecto: 160K€

Líder del proyecto

FUNDACAO D. ANNA DE SOMMER CHAMPALIMAUD E DR.... No se ha especificado una descripción o un objeto social para esta compañía.

TRL 4-5

Ver 2 Participantes

Financiación concedida El organismo H2020 notifico la concesión del proyecto el día 2024-04-27

WF-03-2020: Widening Fellowships

I+D

Cerrada hace 4 años

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2 Participantes

FUNDACAO CHAMPALIMAUD

159.82K€ | Lider

Química del Cinca

321.52K€ | Participante

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Duración del proyecto: 36 meses Fecha Inicio: 2021-04-01
Fecha Fin: 2024-04-27

Líder del proyecto

FUNDACAO D. ANNA DE SOMMER CHAMPALIMAUD E DR.... No se ha especificado una descripción o un objeto social para esta compañía.

TRL 4-5

Presupuesto del proyecto 160K€

Descripción del proyecto "The quality and quantity of consumed nutrients, including proteins, has a significant impact on health and lifespan across phyla. Essential amino acids (eAAs) are an extreme case, as many animals, including humans and Drosophila, cannot efficiently synthesize them, and thus relay solely on protein intake to obtain them. Thus, understanding the molecular changes mediating the organism´s response to such an imbalance is highly important. It is established, that animals respond to a single eAA deficiency behaviorally and metabolically. Evidently, the organism recognizes eAAs-imbalance and translates it into a specific foraging behavior and feeding decisions appropriate for compensating for such specific nutrient deficiency (i.e increased protein preference and feeding). How this is done however remains elusive. We hypothesize that this nutrient imbalance drives molecular changes that are ""mirrored"" in gene transcription in order to drive the response to eAA imbalance, in a tissue specific manner. In this project we will unravel molecular mechanisms involved in the metabolic and behavioral responses to eAAs imbalance , while focusing on protein appetite, in a comprehensive manner. To achieve this, we propose to employ a novel high-throughput RNA sequencing method to decipher tissue specific translational changes following eAAs deprivation. Using a bioinformatic approach, we will look into the processes underlying these transcriptional changes. Interestingly, preliminary data already reveals common biological pathways underlying the response to all eAA deficiencies the fly gut. We will genetic approaches to test the relevance of these pathways to protein feeding and to the physiological response to eAA deficiencies. We foresee this project to open an essential next step in nutritional- neuroscience research, with potential to further our knowledge about the link between stomach, gut and brain signals in driving nutrient homeostasis."

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