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HOst-Transposon Interactions in the MAle GErmline

Transposable elements (TEs) are mobile DNA sequences that have massively colonized mammalian genomes. Host genomes and TEs are engaged in ambiguous trade-offs, whereby TEs can be co-opted for genomic upgrades over evolutionary tim... ver más

31/05/2028

INSERM

2M€

Presupuesto del proyecto: 2M€

Líder del proyecto

INSTITUT NATIONAL DE LA SANTE ET DE LA RECHER... No se ha especificado una descripción o un objeto social para esta compañía.

TRL 4-5

Fecha límite participación Sin fecha límite de participación.

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Financiación concedida El organismo HORIZON EUROPE notifico la concesión del proyecto el día 2023-05-22

ERC-2022-ADG: ERC ADVANCED GRANTS Scope:Objectives

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2 Participantes

INSERM

1.67M€ | Lider

INSTITUT CURIE FONDATION

832.50K€ | Participante

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Duración del proyecto: 60 meses Fecha Inicio: 2023-05-22
Fecha Fin: 2028-05-31

Líder del proyecto

INSTITUT NATIONAL DE LA SANTE ET DE LA RECHER... No se ha especificado una descripción o un objeto social para esta compañía.

TRL 4-5

Presupuesto del proyecto 2M€

Fecha límite de participación Sin fecha límite de participación.

Descripción del proyecto Transposable elements (TEs) are mobile DNA sequences that have massively colonized mammalian genomes. Host genomes and TEs are engaged in ambiguous trade-offs, whereby TEs can be co-opted for genomic upgrades over evolutionary timescales, but they should also be suppressed to protect genome stability and function. Effective and multi-layered surveillance is primordial: TE reactivation is associated with various dysfunctional states, including infertility, ageing, cancer or neurological disorders, involving both transposition-dependent or -independent routes. Understanding the two-way relationship between host genomes and their TE integrants is an essential and fascinating topic, with far-reaching impact on development, evolution and disease. Here I propose to uncover and functionally challenge the molecular arrangements that genomes and TEs came upon for the sake of germline development and fertility. The germline is a highly relevant context, as this is where host-TE interests are the most conflicting, and from their outcome depend reproductive success and species fitness. I will specifically question how TE transcription is transiently tolerated during germline reprogramming and whether it could be purposely used for the early germline program. Using the mouse model, we will deploy innovative and ambitious approaches including in vivo epigenome editing of TE activity, single-cell multimodal profiling, and advanced molecular profiling and microscopy to investigate i) the molecular bases of mutualistic relationships between germ cells and TEs, ii) the dynamic coordination of host-TE interactions within germ cell nuclei, iii) the consequences of dysfunctional host-TE interactions on meiosis. By harnessing our unique expertise and tools and by going beyond correlations, we expect to reveal groundbreaking insights into the molecular transactions in which TEs and host genomes are engaged, and how unbalanced host-TE interactions can lead to disease.

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