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HOLOVIS

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Holographic control of visual circuits

The aim of this research program is to produce novel all-optical technologies to explore brain functions at the mesoscopic scale with cellular resolution opening a new phase in optogenetics that I named circuit optogenetics. Reve... see more

30/09/2026

CNRS

3M€

Project Budget: 3M€

Project leader

CENTRE NATIONAL DE LA RECHERCHE SCIENTIFIQUE... No se ha especificado una descripción o un objeto social para esta compañía.

TRL 4-5

PARTICIPATION DEPralty Sin fecha límite de participación.

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Financing granted El organismo H2020 notifico la concesión del proyecto The day 2020-08-28

ERC-2019-ADG: ERC Advanced Grant Scope:Objectives

I+D

Cerrada does 5 years

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characteristics of the participant

Este proyecto no cuenta con búsquedas de partenariado abiertas en este momento.

Private Information

No hay información privada compartida para este proyecto. Habla con el coordinador.

2 Participantes

CNRS

2.50M€ | Leader

THYSSENKRUPP GALMED, S.A.

2.71M€ | participant

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Project duration: 73 months Date Start: 2020-08-28
End date: 2026-09-30

Project leader

CENTRE NATIONAL DE LA RECHERCHE SCIENTIFIQUE... No se ha especificado una descripción o un objeto social para esta compañía.

TRL 4-5

Project Budget 3M€

participation deadline Sin fecha límite de participación.

Project description The aim of this research program is to produce novel all-optical technologies to explore brain functions at the mesoscopic scale with cellular resolution opening a new phase in optogenetics that I named circuit optogenetics. Revealing the neural codes supporting specific mammalian brain functions is a daunting task demanding to relate in vivo the individual activities of large numbers of neurons recorded jointly within collectives that form distinct nodes of a network and to perform precisely targeted and calibrated interventions in the spatiotemporal dynamics of neural circuits on the scale of naturalistic patterns of activity. Despite recent technical advances, these experiments remain out of reach because we lack a comprehensive approach for large-scale, multi-region, in depth, single cell and millisecond precise manipulation of neural circuits. HOLOVIS will tackle these limitations through the construction of an innovative paradigm combining optogenetics with cutting-edge technology of wave front shaping, compressed sensing, microendoscopy, wave-guide probes, laser developments and opsin engineering. My lab has pioneered the use of wave front shaping for neuroscience and developed in the past years a number of new optical methods, for patterned optogenetic neuronal stimulation. Here, we will push forward this technology and first demonstrate the performances of these breakthrough systems to reveal how inter, intra-laminar and cortical/sub-cortical wiring construct and refine visual orientation selectivity in mice. We will focus on the visual system of mice, whose input-output responses to controlled sensory stimulations have been characterized in decades of studies. However, we are persuaded that our approach can be used to reveal the connectivity rules that underlie specific patterns of activity of any neuronal circuit, thus defining the functional building blocks of distinct brain areas.

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