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MemUnited

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Hippocampus unites Memory Systems by preserving Sequential Order

It is generally assumed that there are two distinct memory systems in the human brain: declarative memory supports memories for facts and events, while the procedural memory supports motor skills. However, recent evidence suggest... ver más

31/05/2025

UGent

222K€

Presupuesto del proyecto: 222K€

Líder del proyecto

UNIVERSITEIT GENT No se ha especificado una descripción o un objeto social para esta compañía.

TRL 4-5

Fecha límite participación Sin fecha límite de participación.

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Financiación concedida El organismo HORIZON EUROPE notifico la concesión del proyecto el día 2022-06-14

HORIZON-MSCA-2021-PF-01-01: MSCA Postdoctoral Fellowships 2021 ExpectedOutcome:

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3 Participantes

UGent

222.00K€ | Lider

TRUSTEES OF COLUMBIA UNIVERS...

N.D. | Participante

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Duración del proyecto: 35 meses Fecha Inicio: 2022-06-14
Fecha Fin: 2025-05-31

Líder del proyecto

UNIVERSITEIT GENT No se ha especificado una descripción o un objeto social para esta compañía.

TRL 4-5

Presupuesto del proyecto 222K€

Fecha límite de participación Sin fecha límite de participación.

Descripción del proyecto It is generally assumed that there are two distinct memory systems in the human brain: declarative memory supports memories for facts and events, while the procedural memory supports motor skills. However, recent evidence suggests that these multiple memory systems are less independent than originally thought and that the hippocampus, historically associated with declarative memory, is also involved in procedural motor memory. Accordingly, the project MemUnited (Hippocampus unites Memory Systems by preserving Sequential Order) proposes and tests an integrative framework that specifies the shared neural processes that support learning and memory across multiple memory systems. Specifically, given that declarative episodic and procedural motor memories consist of temporally organized sequences of events (e.g. order in which guests arrived at your dinner party) and movements (e.g. playing the piano), and the hippocampus is critical to preserve sequential order of experiences, I will investigate whether the neural mechanisms of sequential order processing supported by the hippocampus are jointly used in declarative episodic and procedural motor memory. To do so I will use state-of-the-art multivariate pattern analyses of functional Magnetic Resonance Imaging data acquired during the different phases of memory formation (i.e., encoding, consolidation and retrieval). Findings in the proposed research will fill a gap in the field by providing a detailed characterization of the role of the hippocampus in multiple memory systems. The findings will offer the opportunity to reconsider the historical models of memory classification and develop more integrative views of memory organization in general and hippocampal functioning in particular. Moreover, it will open new avenues for the development of integrative treatment of procedural and declarative memory deficits.

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