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MAGNEURON

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Hijacking cell signalling pathways with magnetic nanoactuators for remote contro...

Hijacking cell signalling pathways with magnetic nanoactuators for remote controlled stem cell therapies of neurodegenerative disorders Neurodegenerative diseases, such as Parkinson’s disease, are a major public health issue given the aging population in Europe and beyond. While curative pharmacological treatment of these diseases is not in sight, cell replacement... ver más

31/12/2019

INSTITUT CURIE FON...

3M€

Presupuesto del proyecto: 3M€

Líder del proyecto

INSTITUT CURIE No se ha especificado una descripción o un objeto social para esta compañía.

TRL 4-5

Fecha límite participación Sin fecha límite de participación.

Ver 8 Participantes

Financiación concedida El organismo H2020 notifico la concesión del proyecto el día 2019-12-31

FETOPEN-RIA-2014-2015: FET-Open research projects Scope:Specific challenge: Supporting a large set of early stage, high risk visionary science and tec...

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Este proyecto no cuenta con búsquedas de partenariado abiertas en este momento.

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8 Participantes

INSTITUT CURIE FONDATION

638.75K€ | Lider

KEELE UNIVERSITY

808.28K€ | Participante

EFFICIENT INNOVATION

150.00K€ | Participante

UoB

51.84K€ | Participante

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Duración del proyecto: 49 meses Fecha Inicio: 2015-11-04
Fecha Fin: 2019-12-31

Líder del proyecto

INSTITUT CURIE No se ha especificado una descripción o un objeto social para esta compañía.

TRL 4-5

Presupuesto del proyecto 3M€

Fecha límite de participación Sin fecha límite de participación.

Descripción del proyecto Neurodegenerative diseases, such as Parkinson’s disease, are a major public health issue given the aging population in Europe and beyond. While curative pharmacological treatment of these diseases is not in sight, cell replacement therapies (CTs) are considered very promising, in particular with the advent of stem-cell reprogramming technologies. However, a fundamental challenge in the medical application of CTs in the brain of patients lies in the lack of control of cell behaviour at the site of transplantation, and particularly their differentiation and oriented growth. The aim of this project is to introduce a fundamentally new concept for remote control of cellular functions by means of magnetic manipulation. The technology is based on magnetic nanoparticles functionalized with proteins involved in cellular signalling cascades. These biofunctionalized MNPs (bMNPs) will be delivered into target cells, where they act as intracellular signalling platforms activatable in a spatially and temporally controlled manner by external magnetic fields. The project will focus on engineering these tools for the control of neuronal cell programming and fibre outgrowth by hijacking Wnt and neurotrophin signalling, respectively, with the ulti-mate objective of advancing cell replacement therapies for PD using dopaminergic precursor neurons. To achieve this ambitious goal, we have gathered an interdisciplinary consortium interfacing scientists having cutting-edge know-how in bMNP engineering, surface functionalization and cellular nanobiophysics with renowned experts in neuronal cell differentiation, stem-cell reprogramming and regenerative (nano-)medicine. By exploiting this complementary expertise, a novel, versatile technology for magnetic control of intracellular signalling is envis-aged, which will be a breakthrough for remote actuation of cellular functions and its successful implementation in CTs for neurodegenerative diseases and injuries within the following decade.

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