TextaDNA
Financiado
High-throughput oligonucleotide synthesis and NGS for Digital TEXT Storage And r...
High-throughput oligonucleotide synthesis and NGS for Digital TEXT Storage And retrieval in DNA encapsulated nanofibers
Incorporating biomolecules as integral parts of computational systems represents a frontier challenge in bio and nanotechnology. Using DNA to store digital data is an attractive alternative to conventional information technologies...
Incorporating biomolecules as integral parts of computational systems represents a frontier challenge in bio and nanotechnology. Using DNA to store digital data is an attractive alternative to conventional information technologies due to its high information density and long lifetime. However, developing an adequate DNA storage medium remains a significant challenge in permitting the safe archival and retrieval of oligonucleotides.
TextaDNA introduces polymer fibres as a novel approach to encapsulating and retrieving information-carrying oligonucleotides. We will develop a complete DNA storage workflow, encoding digital information into DNA base sequences and optimising oligonucleotide synthesis and encapsulation in polymer nano and microfibres. The project is led by nanoGUNE, a nanotechnology research centre, and partners with Eurofins, a leading European company specialising in state-of-art oligo synthesis and next-generation sequencing. We will design next-generation sequencing assays to automate the DNA digital storage readout retrieved from fibres. The enhanced oligo synthesis and sequencing strategies that, TextaDNA will develop are of fundamental interest in the path toward broader use of DNA digital storage, increasing synthesis speed and length of oligos and reducing costs. The consortium will create the conditions for encapsulating oligonucleotides inside polymer fibres and methods to retrieve them. We will establish efficient methods of synthesising oligonucleotides going beyond state-of-art phosphorodiamidate chemistry while ensuring their stability. Further, TextaDNA will also explore ways of incorporating sequencing technologies into reading digital data stored in oligonucleotide pools and expand the data storage capabilities of DNA.
TextaDNA will add to the European leadership in DNA data digital storage by leveraging oligo synthesis and sequencing with nanotechnology to build DNA digital storage materials.
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Duración del proyecto: 51 meses
Fecha Inicio: 2023-10-30
Fecha Fin: 2028-01-31
Fecha Fin: 2028-01-31
Línea de financiación: concedida
El organismo HORIZON EUROPE notifico la concesión del proyecto el día 2023-10-30
Línea de financiación objetivo
El proyecto se financió a través de la siguiente ayuda:
Presupuesto
El presupuesto total del proyecto asciende a
3M€
Líder del proyecto
ASOC CIC NANOGUNE
Actividades auxiliares a la educación asociacion
Perfil tecnológico
TRL
4-5
50K
Perfil tecnológico
TRL
4-5
50K
1.35M€ |
Participante