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HiChemSynPro

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High throughput combinatorial chemical protein synthesis as a novel research tec...

High throughput combinatorial chemical protein synthesis as a novel research technology platform for chemical and synthetic biology Chemical protein synthesis is an indispensable method in chemical and synthetic biology. However, at the present moment, it is laborious and involves multiple optimization and purification steps. High-throughput approaches for tot... ver más

28/02/2023

FONDATION EUROPEEN...

2M€

Presupuesto del proyecto: 2M€

Líder del proyecto

FONDATION EUROPEENNE DE LA SCIENCE No se ha especificado una descripción o un objeto social para esta compañía.

Ver 3 Participantes

Financiación concedida El organismo H2020 notifico la concesión del proyecto el día 2023-02-28

ERC-2016-STG: ERC Starting Grant

I+D

Cerrada hace 9 años

0% 100% 100%

3 Participantes

FONDATION EUROPEENNE DE LA S...

1.50M€ | Lider

LABORATORIOS KARIZOO

390.00K€ | Participante

UNISTRA

970.08K€ | Participante

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Duración del proyecto: 75 meses Fecha Inicio: 2016-11-23
Fecha Fin: 2023-02-28

Líder del proyecto

FONDATION EUROPEENNE DE LA SCIENCE No se ha especificado una descripción o un objeto social para esta compañía.

Presupuesto del proyecto 2M€

Descripción del proyecto Chemical protein synthesis is an indispensable method in chemical and synthetic biology. However, at the present moment, it is laborious and involves multiple optimization and purification steps. High-throughput approaches for total synthesis of combinatorial libraries of custom-modified protein variants are needed. To change the situation, the work will be carried out in two directions: (1) implementation of microfluidic techniques for automation, miniaturization and multiplexing of experimental steps involved in the total synthesis of proteins, and (2) design and synthesis of novel catalytic proteins for efficient enzyme-assisted peptide ligations under denatured conditions. This innovative research technology will allow robust chemical synthesis of protein libraries with (100–10,000)-compounds with natural and unnatural modifications, bearing variety of post-translational modifications and also protein-like biopolymers. In this project, the new methodology will be validated by chemical synthesis of library of phosphorylated analogues of high mobility group protein A (HMGA), which is involved in gene-transcription and cancer development. Other potential future applications include protein design, biological problems where post-translational modifications play a crucial role (ranging from the ‘histone code’ hypothesis to understanding long-term memory) and functional annotation of newly discovered genes.

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