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NANO4LIFE

Financiado

High throughput 4D imaging for nanoscale cellular studies

Fluorescence microscopy is an invaluable tool for exploring the structure and function of biological processes. It provides high specificity and contrast for the observation of cellular components tagged with fluorescent molecules... ver más

31/12/2025

FORSCHUNGSINSTITUT...

2M€

Presupuesto del proyecto: 2M€

Líder del proyecto

FORSCHUNGSINSTITUT FUR MOLEKULARE PATHOLOGIE... No se ha especificado una descripción o un objeto social para esta compañía.

TRL 4-5

Ver 2 Participantes

Financiación concedida El organismo H2020 notifico la concesión del proyecto el día 2019-10-02

ERC-2019-STG: ERC Starting Grant

I+D

Cerrada hace 6 años

0% 100% 100%

2 Participantes

FORSCHUNGSINSTITUT FUR MOLEK...

1.78M€ | Lider

CELAYA EMPARANZA Y GALDOS IN...

595.08K€ | Participante

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Duración del proyecto: 74 meses Fecha Inicio: 2019-10-02
Fecha Fin: 2025-12-31

Líder del proyecto

FORSCHUNGSINSTITUT FUR MOLEKULARE PATHOLOGIE... No se ha especificado una descripción o un objeto social para esta compañía.

TRL 4-5

Presupuesto del proyecto 2M€

Descripción del proyecto Fluorescence microscopy is an invaluable tool for exploring the structure and function of biological processes. It provides high specificity and contrast for the observation of cellular components tagged with fluorescent molecules in a minimally invasive fashion, allowing the study of live specimens. Furthermore, the development of super resolution (SR) fluorescence microscopy has unlocked the access to spatial resolutions beyond the diffraction limit of visible light (~250nm), fuelling the discovery of new biological structures and dynamics. Nevertheless, achieving resolutions below ~10nm is challenged by multiple trade-offs between spatial and temporal resolutions, depth of observation and photo toxicity, making it difficult or impossible to obtain a molecular resolution. Additionally, axial resolutions are inevitably poorer than lateral ones, unless utilizing a complex multi-objective lens approach. I recently developed MINFLUX, a localization technique that merges concepts of SR with information theory. It achieves isotropic nanometer resolution in three dimensions with a single objective lens and has unrivaled spatio temporal resolution. However, a platform that enables these capabilities in a high-throughput manner for entire cells and tissue has not yet been developed. I aim to fill this technological gap; with my background and experience, I am in a unique position to assure the success of this project and establish these technologies in the scientific community. The performance of fluorescence imaging and tracking will progress orders of magnitude in the years to come, signaling yet another revolution for optical nanoscopy.

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