HGF-INSR
Financiado
Hepatocyte Growth Factor and Insulin Resistance
Insulin resistance is a hallmark of human diseases, including diabetes and obesity, which lead to abnormal glucose and lipid metabolism as a result of impaired metabolic response to insulin. The mechanism underlying the developmen...
Insulin resistance is a hallmark of human diseases, including diabetes and obesity, which lead to abnormal glucose and lipid metabolism as a result of impaired metabolic response to insulin. The mechanism underlying the development of insulin resistance remains incompletely understood. Excessive production of pro-inflammatory cytokines by the adipose tissue is linked to insulin resistance. Hepatocyte Growth Factor (HGF) is an adipocytokine elevated in obese subjects, which strongly correlated with the metabolic syndrome. However the role of HGF in the etiology of the insulin resistance remains unknown. Recently, we have demonstrated that HGF is a potent activator of glucose transport and metabolism, and also a strong inhibitor of fatty acid oxidation in rodent myotubes (Perdomo et al., J. Biol. Chem., 2008). In addition, we have generated (i) a conditional transgenic mouse of HGF in the skeletal muscle, and (ii) a conditional knockout mouse of the HGF receptor (c-met) in skeletal muscle. We hypothesized that HGF ameliorates skeletal muscle insulin resistance in vivo. To test this hypothesis, we propose two aims: 1) To investigate the relationship between plasma HGF levels and insulin resistance in humans. 2) To investigate the role of HGF in the insulin-resistant skeletal muscle. Accomplishing this project will elucidate the relationship between plasma HGF levels and insulin resistance in humans and determine its contribution to the etiology and pathophysiology of insulin resistance. A mechanistic understanding of insulin resistance will facilitate the development of therapeutic strategies and identification of new drug targets in the prevention and treatment of diabetes and obesity. Finally, my preliminary data have provided feasibility for the project.
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Línea de financiación: concedida
El organismo FP7 notifico la concesión del proyecto el día 2014-05-31
Presupuesto
El presupuesto total del proyecto asciende a
100K€
Líder del proyecto
UNIVERSIDAD DE CASTILLA-LA MANCHA
No se ha especificado una descripción o un objeto social para esta compañía.
Total investigadores
2583
Total investigadores
2583