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CISTEM

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Heart On chip based on induced pluripotent Stem cell Technology for personalized...

Heart On chip based on induced pluripotent Stem cell Technology for personalized Medicine Many rare diseases cause chronic health problems or are even life-threatening. The impact on the quality of life of affected patients, of whom many are children, is significant. To date, a limited but increasing number of so-call... ver más

30/06/2023

BIOSENSE INSTITUTE

365K€

Presupuesto del proyecto: 365K€

Líder del proyecto

BIOSENSE INSTITUTE RESEARCH AND DEVELOPMENT... No se ha especificado una descripción o un objeto social para esta compañía.

TRL 4-5

Fecha límite participación Sin fecha límite de participación.

Ver 10 Participantes

Financiación concedida El organismo H2020 notifico la concesión del proyecto el día 2023-06-30

MSCA-RISE-2017: Research and Innovation Staff Excha...

I+D

Cerrada hace 7 años

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Información adicional privada

No hay información privada compartida para este proyecto. Habla con el coordinador.

10 Participantes

BIOSENSE INSTITUTE

184.50K€ | Lider

RUTGERS, THE STATE UNIVERSIT...

UNIWERSYTET JAGIELLONSKI

40.50K€ | Participante

CHERRY BIOTECH

27.00K€ | Participante

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Duración del proyecto: 68 meses Fecha Inicio: 2017-10-04
Fecha Fin: 2023-06-30

Líder del proyecto

BIOSENSE INSTITUTE RESEARCH AND DEVELOPMENT... No se ha especificado una descripción o un objeto social para esta compañía.

TRL 4-5

Presupuesto del proyecto 365K€

Fecha límite de participación Sin fecha límite de participación.

Descripción del proyecto Many rare diseases cause chronic health problems or are even life-threatening. The impact on the quality of life of affected patients, of whom many are children, is significant. To date, a limited but increasing number of so-called orphan drugs (drugs for rare diseases) are reaching patients. However, the majority of rare diseases are still without any effective treatment. The development of novel human systems for drug discovery therefore represents a major public health priority. Microfluidic technology-based Organs-on-a-chip represents a powerful tool for investigating rare disease mechanisms and testing new drug and treatment due to their ability to mimic tailored micro-environment architecture inspired by organ-level functions in vivo. However, due to the variability in rare disease mechanisms from one patient to another, organ on chip technology needs to be more precise and to convey towards personalized medicine. The human-induced pluripotent stem cells (iPSCs) have a strong potential in engineering organ-on-a-chip since they are derived in a patient-matched manner which makes them a superb source to construct human models for personalized drug screening as well as for understanding patient-specific fundamentals of diseases. To provide novel miniaturized platform for investigation of rare diseases able to address the burning issues in precision medicine today, CISTEM will bring together and synergistically several highly promising research directions which are too often investigated separately at the academic level but also at the industrial level. Based on 4 work packages, the CISTEM RISE project will be implemented by exploiting the complementary expertise of its partners and creating synergies between them through the targeted secondments of staff.

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