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NanoHeadTail

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Head to tail imaging of fluorescent carbon nanotubes for the characterization of...

Head to tail imaging of fluorescent carbon nanotubes for the characterization of the brain extracellular space The NanoHeadTail proposes a novel and original approach combining fluorescence microscopy and nanotechnology to resolve the morphological and rheological properties of the brain extracellular space (ECS) at the nanoscale. Current... ver más

31/08/2025

IOTA

212K€

Presupuesto del proyecto: 212K€

Líder del proyecto

INSTITUT DOPTIQUE THEORIQUE ET APPLIQUEE IOTA... No se ha especificado una descripción o un objeto social para esta compañía.

TRL 4-5

Fecha límite participación Sin fecha límite de participación.

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Financiación concedida El organismo HORIZON EUROPE notifico la concesión del proyecto el día 2023-05-11

HORIZON-MSCA-2022-PF-01-01: MSCA Postdoctoral Fellowships 2022 Expected Outcome:

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Este proyecto no cuenta con búsquedas de partenariado abiertas en este momento.

Información adicional privada

No hay información privada compartida para este proyecto. Habla con el coordinador.

3 Participantes

IOTA

211.75K€ | Lider

UBx

N.D. | Participante

CNRS

N.D. | Participante

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Duración del proyecto: 27 meses Fecha Inicio: 2023-05-11
Fecha Fin: 2025-08-31

Líder del proyecto

INSTITUT DOPTIQUE THEORIQUE ET APPLIQUEE IOTA... No se ha especificado una descripción o un objeto social para esta compañía.

TRL 4-5

Presupuesto del proyecto 212K€

Fecha límite de participación Sin fecha límite de participación.

Descripción del proyecto The NanoHeadTail proposes a novel and original approach combining fluorescence microscopy and nanotechnology to resolve the morphological and rheological properties of the brain extracellular space (ECS) at the nanoscale. Current methods allow to determine the local dimensions and fluidity of the ECS, but they do not allow to resolve its structural complexity and are limited to an analysis in 2D. This project proposes the simultaneous monitoring of the position, the translational and rotational diffusion of fluorescent probes over time and in 3D, allowing to determine the volumetric structure, fluidity and inner organization of the ECS locally. For that, a novel type of asymmetric probes will be designed based on the localized functionalization of single-walled carbon nanotubes with fluorescent color centers at their ends, analyzed using a custom cutting-edge fluorescence microscope and tested in live brain tissues from mice models of the Parkinson’s disease. The applicant will bring his strong expertise in the photophysics and chemistry of carbon nanotubes, critical for the preparation of the probes. In parallel, the fellow will gain a high-level hands-on training on optics assembly, super resolution microscopy and single particle tracking, imaging analysis and neurosciences. The project will be performed at the IOGS-LP2N (CNRS/Univ. Bordeaux), a leading French research institution, under the supervision of Dr. Laurent Cognet expert in the single particle tracking of nanoobjects. The proposal contains well-identified work packages which will ensure efficient science development but also project management, career development, training, technology transfer and communication. The fellow’s expertise, the hosting lab, the infrastructure, facilities and the mentoring will guarantee the successful execution of the NanoHeadTail goals and will allow the applicant to reach a high level of professional maturity and to develop his career as an independent researcher.

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