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PROMICON

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HARNESSING THE POWER OF NATURE THROUGH PRODUCTIVE MICROBIAL CONSORTIA IN BIOTECH...

HARNESSING THE POWER OF NATURE THROUGH PRODUCTIVE MICROBIAL CONSORTIA IN BIOTECHNOLOGY MEASURE MODEL MASTER The deliberate control of complex microbiomes is notoriously difficult and current approaches are often guided by simple trial-and-error. Advances in quantitative analysis modelling and design of these systems are urgently needed... ver más

31/05/2025

HELMHOLTZZENTRUM F...

6M€

Presupuesto del proyecto: 6M€

Líder del proyecto

HELMHOLTZZENTRUM FUR UMWELTFORSCHUNG GMBH UF... No se ha especificado una descripción o un objeto social para esta compañía.

TRL 4-5

Fecha límite participación Sin fecha límite de participación.

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Financiación concedida El organismo H2020 notifico la concesión del proyecto el día 2021-05-03

FNR-12-2020: Industrial microbiomes – learning f...

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12 Participantes

HELMHOLTZZENTRUM FUR UMWELTF...

1.27M€ | Lider

GALENICUM HEALTH

1.49M€ | Participante

PENSOFT

253.75K€ | Participante

BIOPOLIS

550.00K€ | Participante

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Duración del proyecto: 48 meses Fecha Inicio: 2021-05-03
Fecha Fin: 2025-05-31

Líder del proyecto

HELMHOLTZZENTRUM FUR UMWELTFORSCHUNG GMBH UF... No se ha especificado una descripción o un objeto social para esta compañía.

TRL 4-5

Presupuesto del proyecto 6M€

Fecha límite de participación Sin fecha límite de participación.

Descripción del proyecto The deliberate control of complex microbiomes is notoriously difficult and current approaches are often guided by simple trial-and-error. Advances in quantitative analysis modelling and design of these systems are urgently needed to improve the predictability and enable exploitation of the amazing synthesis capacities of microbiomes. The PROMICON project will learn from nature how microbiomes function through development and application of quantitative physiology, imaging, cell sorting machine learning and systems biology. This will be used to steer existing microbiomes towards production and to generate new synthetic microbiomes inspired by nature through an iterative design-build-test-learn cycle. The new consortia will also contain strains developed through systems metabolic engineering and will be used for the production of energy carriers, drop-in chemical feedstocks and advanced biomaterials. PROMICON will advance characterization tools to understand which strains (modules) are needed for a successful microbiome. It will identify the primary producers (farmers), secondary converters (labourers) and essential strains for microbiome stability (balancers). This knowledge will be used to reduce complexity of natural microbiomes for optimized production of phycobilli protein based pigments, exo-polysaccharides (EPS) and poly-hydroxyalkanoates (PHA) in a top-down approach. Secondly, synthetic microbiomes with increasing complexity (bottom-up) will be assembled for the production of butanol, H2 and PHACOS, a functionalized antimicrobial polyester. PROMICON will develop new reactor concepts and downstream processing for microbiomes and conduct early-stage life cycle assessment (LCA) to prepare exploitation. This ground-breaking project will not only inspire completely new production pathways and a paradigm shift from monocultures to mixed cultures in biotechnology, but also has the potential beyond biotechnology to inspire novel treatment options in biomedicine.

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