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CREADOZE

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Harnessing the cognitive and neurophysiological processes characterising the sle...

Harnessing the cognitive and neurophysiological processes characterising the sleep onset period Sleep often escapes us when we need it or intrudes when we would prefer to stay awake. What if we could control when we fall asleep? While our understanding of sleep has rapidly grown, what happens during the wake to sleep transit... ver más

30/09/2028

INSERM

2M€

Presupuesto del proyecto: 2M€

Líder del proyecto

INSTITUT NATIONAL DE LA SANTE ET DE LA RECHER... No se ha especificado una descripción o un objeto social para esta compañía.

TRL 4-5

Fecha límite participación Sin fecha límite de participación.

Financiación concedida El organismo HORIZON EUROPE notifico la concesión del proyecto el día 2023-04-06

ERC-2022-COG: ERC CONSOLIDATOR GRANTS Scope:Objectives

I+D

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Este proyecto no cuenta con búsquedas de partenariado abiertas en este momento.

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1 Participantes

INSERM

2.00M€ | Lider

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Duración del proyecto: 65 meses Fecha Inicio: 2023-04-06
Fecha Fin: 2028-09-30

Líder del proyecto

INSTITUT NATIONAL DE LA SANTE ET DE LA RECHER... No se ha especificado una descripción o un objeto social para esta compañía.

TRL 4-5

Presupuesto del proyecto 2M€

Fecha límite de participación Sin fecha límite de participación.

Descripción del proyecto Sleep often escapes us when we need it or intrudes when we would prefer to stay awake. What if we could control when we fall asleep? While our understanding of sleep has rapidly grown, what happens during the wake to sleep transition remains mysterious, potentially due to the widespread assumption that we are either awake or asleep. The current standard is to define vigilance states through coarse, physiological criteria that are visually assessed on fixed, 30s-epochs. In this framework, the sleep onset period (SOP) typically corresponds to the first sleep stage. Yet, this classification in discrete sleep stages fails to account for the gradual, dynamic changes observed in the descent to sleep, on the behavioral (reduced responsiveness to stimuli), subjective (dream-like experiences called hypnagogia) and cognitive level (decline in executive functions, enhanced creativity). To better understand how we transition from full vigilance to sleep, I propose to integrate, within the same framework the many dimensions of the sleep onset process. I hypothesize that the behavioral, subjective, and cognitive changes associated with the SOP are each reflected by specific neurophysiological signatures that are partially independent of sleep stages. I recently found candidate physiological markers for the different SOP dimensions. In CREADOZE, I will leverage on these findings to refine in space and time the neurophysiological signatures reflecting the processes which decline (behavioral responsiveness, executive abilities) and those which emerge (hypnagogia, creativity) during the SOP, using multimodal physiological recordings. I will explore how these markers fluctuate in relation to each other and identify potential factors influencing them (sleep pressure; sleep disorder). Then, I will use neurofeedback to train individuals to either resist or embrace sleep. If successful, this proposal will open the possibility to harness the sleep onset period depending on one’s needs.

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