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SmartAge

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Cerrado

Gut brain axis Targets for improvement of cognition in the elderly

In Europe, the population is aging. The age-associated decline in cognitive functions represents a serious social and medical problem. Recent studies show that changes in lifestyle such as physical activity and nutritional interve... ver más

28/02/2025

UNIVERSITATSKLINIK...

4M€

Presupuesto del proyecto: 4M€

Líder del proyecto

UNIVERSITATSKLINIKUM JENA No se ha especificado una descripción o un objeto social para esta compañía.

TRL 4-5

Fecha límite participación Sin fecha límite de participación.

Ver 13 Participantes

Financiación concedida El organismo H2020 notifico la concesión del proyecto el día 2025-02-28

MSCA-ITN-2019: Innovative Training Networks Objective:The Innovative Training Networks (ITN) aim to train a new generation of creative, entrepre...

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Este proyecto no cuenta con búsquedas de partenariado abiertas en este momento.

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13 Participantes

UNIVERSITATSKLINIKUM JENA

758.37K€ | Lider

ICAR VISION SYSTEMS

263.96K€ | Participante

ETH Zürich

281.28K€ | Participante

EDEN TECH

274.80K€ | Participante

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Duración del proyecto: 56 meses Fecha Inicio: 2020-06-22
Fecha Fin: 2025-02-28

Líder del proyecto

UNIVERSITATSKLINIKUM JENA No se ha especificado una descripción o un objeto social para esta compañía.

TRL 4-5

Presupuesto del proyecto 4M€

Fecha límite de participación Sin fecha límite de participación.

Descripción del proyecto In Europe, the population is aging. The age-associated decline in cognitive functions represents a serious social and medical problem. Recent studies show that changes in lifestyle such as physical activity and nutritional interventions – even late in life –are beneficial for cognition. The microbiome in the gut is a central effector in the maintenance of brain plasticity and therefore represents a promising target as well as sensor for interventions that aim to improve cognitive ability in the elderly. Detailed and concise scientific investigations of gut-brain interactions, in particular in the elderly, are limited. Such studies require a multidisciplinary approach and a combination of experts from various fields. The aim of our network is to train a new generation of young scientists within a multidisciplinary consortium. The ESRs will engage in individual and well defined, jointly supervised research projects, securing excellent career perspectives and employability. By enabling ESRs to design and conduct studies in this economically and socially important field, SmartAge will elucidate the role of the microbiome-gut-brain axis in aging and its impact on cognition. SmartAge will apply a translational approach combining animal and human studies, nutritional and life style interventions, cognitive tests, brain imaging, cutting edge OMICS and systems biology as well as fecal transfer as proof of principle to identify key regulators of gut-brain communication with the aim to develop microbiome-based therapies. An expert team of scientists from both academia and industry such as clinicians, psychologists, nutritionists, biotechnologists and bioinformaticians will closely collaborate to strengthen microbiome research in aging which will have a direct impact on cognitive health in Europe. Specialists for public communication outreach will ensure effective and efficient transfer of outcomes to policy makers and into the everyday life of the European population.

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