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GLYCOFOLD

Financiado

Glycan foldamers: designing oligosaccharides to build three-dimensional architec...

Natural biopolymers have inspired the development of synthetic analogues – i.e. foldamers – capable of adopting defined conformations and forming programmable three-dimensional architectures. These compounds are mainly based on pe... ver más

31/12/2027

MPG

1M€

Presupuesto del proyecto: 1M€

Líder del proyecto

MAXPLANCKGESELLSCHAFT ZUR FORDERUNG DER WISSE... No se ha especificado una descripción o un objeto social para esta compañía.

TRL 4-5

Financiación concedida El organismo HORIZON EUROPE notifico la concesión del proyecto el día 2022-11-21

Línea de financiación objetivo El proyecto se financió a través de la siguiente ayuda:

ERC-2022-STG: ERC STARTING GRANTS

I+D

Cerrada hace 2 años

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1 Participantes

MPG

1.50M€ | Lider

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Últimas noticias

01-12-2024: REDES En las últimas 48 horas el Organismo REDES ha otorgado 1337 concesiones

01-12-2024: IDAE En las últimas 48 horas el Organismo IDAE ha otorgado 4 concesiones

01-12-2024: AEI En las últimas 48 horas el Organismo AEI ha otorgado 23 concesiones

Duración del proyecto: 61 meses Fecha Inicio: 2022-11-21
Fecha Fin: 2027-12-31

Presupuesto del proyecto 1M€

Descripción del proyecto Natural biopolymers have inspired the development of synthetic analogues – i.e. foldamers – capable of adopting defined conformations and forming programmable three-dimensional architectures. These compounds are mainly based on peptides and nucleic acids, that are well understood at the molecular level. The diversity, intrinsic chirality, and ability to generate hierarchical assemblies suggest that carbohydrates hold an even larger potential for the generation of three-dimensional structures. However, the complexity of carbohydrate synthesis and structural analysis have prevented access to synthetic carbohydrates capable of adopting defined geometries. I propose the creation of carbohydrate foldamers capable of 1) adopting rigid secondary structures and 2) assembling into supramolecular architectures. To achieve these goals, we will address fundamental questions related to carbohydrate structure, design new methods to stabilize particular conformations, and we will implement protocols for systematic structural analysis. State-of-the-art synthetic platforms (i.e. automated glycan assembly) and analytical techniques (i.e. NMR spectroscopy, microED, and single molecule imaging) will be the tools to complete this ambitious project. My group has proved to be very successful at gaining a basic understanding of carbohydrate structure and aggregation. Building upon these preliminary results, I aim to develop programmable carbohydrate architectures, which have the potential to open a new field of carbohydrate and supramolecular chemistry. Analogous to the birth of a new field after the discovery of peptide-based foldamers, carbohydrate foldamers could find applications in several areas, including material science, biology, and catalysis. Moreover, carbohydrate foldamers will expand our understanding of carbohydrate structures and interactions, and new analytical protocols will standardize the characterization of carbohydrate materials.

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