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GLYCOFOLD

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Glycan foldamers: designing oligosaccharides to build three-dimensional architec...

Glycan foldamers: designing oligosaccharides to build three-dimensional architectures Natural biopolymers have inspired the development of synthetic analogues – i.e. foldamers – capable of adopting defined conformations and forming programmable three-dimensional architectures. These compounds are mainly based on pe... see more

31/12/2027

MPG

1M€

Project Budget: 1M€

Project leader

MAXPLANCKGESELLSCHAFT ZUR FORDERUNG DER WISSE... No se ha especificado una descripción o un objeto social para esta compañía.

TRL 4-5

PARTICIPATION DEPralty Sin fecha límite de participación.

Financing granted El organismo HORIZON EUROPE notifico la concesión del proyecto The day 2022-11-21

ERC-2022-STG: ERC STARTING GRANTS Scope:Objectives

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characteristics of the participant

Este proyecto no cuenta con búsquedas de partenariado abiertas en este momento.

Private Information

No hay información privada compartida para este proyecto. Habla con el coordinador.

1 Participantes

MPG

1.50M€ | Leader

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Project duration: 61 months Date Start: 2022-11-21
End date: 2027-12-31

Project leader

MAXPLANCKGESELLSCHAFT ZUR FORDERUNG DER WISSE... No se ha especificado una descripción o un objeto social para esta compañía.

TRL 4-5

Project Budget 1M€

participation deadline Sin fecha límite de participación.

Project description Natural biopolymers have inspired the development of synthetic analogues – i.e. foldamers – capable of adopting defined conformations and forming programmable three-dimensional architectures. These compounds are mainly based on peptides and nucleic acids, that are well understood at the molecular level. The diversity, intrinsic chirality, and ability to generate hierarchical assemblies suggest that carbohydrates hold an even larger potential for the generation of three-dimensional structures. However, the complexity of carbohydrate synthesis and structural analysis have prevented access to synthetic carbohydrates capable of adopting defined geometries. I propose the creation of carbohydrate foldamers capable of 1) adopting rigid secondary structures and 2) assembling into supramolecular architectures. To achieve these goals, we will address fundamental questions related to carbohydrate structure, design new methods to stabilize particular conformations, and we will implement protocols for systematic structural analysis. State-of-the-art synthetic platforms (i.e. automated glycan assembly) and analytical techniques (i.e. NMR spectroscopy, microED, and single molecule imaging) will be the tools to complete this ambitious project. My group has proved to be very successful at gaining a basic understanding of carbohydrate structure and aggregation. Building upon these preliminary results, I aim to develop programmable carbohydrate architectures, which have the potential to open a new field of carbohydrate and supramolecular chemistry. Analogous to the birth of a new field after the discovery of peptide-based foldamers, carbohydrate foldamers could find applications in several areas, including material science, biology, and catalysis. Moreover, carbohydrate foldamers will expand our understanding of carbohydrate structures and interactions, and new analytical protocols will standardize the characterization of carbohydrate materials.

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