Hola,
¿eres nuevo aquí?

Regístrate gratis y conecta tu empresa con financiación pública, partners y proyectos.

Tengo cuenta

Regístrate

Ver video

MTLE-HS

Financiado

Cerrado

Genomic sequence variants that correlate with gene expression and different epig...

Genomic sequence variants that correlate with gene expression and different epigenetic patterns modify risk for mTLE HS Epilepsy is the second most common neurological disorder after stroke and mesial temporal lobe epilepsy with hippocampal sclerosis (mTLE+HS) represents the most common epilepsy syndrome in adult patient with medically intractable... ver más

30/06/2012

UNIVERSITY COLLEGE...

56K€

Presupuesto del proyecto: 56K€

Líder del proyecto

UNIVERSITY COLLEGE LONDON No se ha especificado una descripción o un objeto social para esta compañía.

Fecha límite participación Sin fecha límite de participación.

Ver 2 Participantes

Financiación concedida El organismo FP7 notifico la concesión del proyecto el día 2012-06-30 No tenemos la información de la convocatoria

0% 100% 100%

Información adicional privada

No hay información privada compartida para este proyecto. Habla con el coordinador.

2 Participantes

UNIVERSITY COLLEGE LONDON

56.25K€ | Lider

UNIVERSITY COLLEGE LONDON

Conecta tu I+D

¿Tienes un proyecto y buscas un partner? Gracias a nuestro motor inteligente podemos recomendarte los mejores socios y ponerte en contacto con ellos. Te lo explicamos en este video

Proyectos interesantes

IGENEE Identification of pathways and genetic drivers for childhood... 231K€ Cerrado

EPIMIRNA MicroRNAs in the Pathogenesis Treatment and Prevention of E... 16M€ Cerrado

PTQ2019-010706 Genética para todos: desarrollo de un mini-panel de NGS de l... 77K€ Cerrado

EPIPGX Epilepsy Pharmacogenomics delivering biomarkers for clinica... 8M€ Cerrado

Epi4MS Targeting the epigenome towards a better understanding of d... 2M€ Cerrado

PGXOME A pharmacogenomic exploration of adverse drug reactions in e... 83K€ Cerrado

Líder del proyecto

UNIVERSITY COLLEGE LONDON No se ha especificado una descripción o un objeto social para esta compañía.

Presupuesto del proyecto 56K€

Fecha límite de participación Sin fecha límite de participación.

Descripción del proyecto Epilepsy is the second most common neurological disorder after stroke and mesial temporal lobe epilepsy with hippocampal sclerosis (mTLE+HS) represents the most common epilepsy syndrome in adult patient with medically intractable partial epilepsy. Studies of genome-wide association (GWA) with epilepsy are critical to provide an unbiased assessment of genes contributing to disease risk and/or response to treatment. However the results of GWA studies give little information about the underlying disease mechanisms. The proposed research project will try to identify those genomic sequence variants that correlate with gene expression and different epigenetic patterns that could modify risk for mTLE+HS. Starting with an already established epilepsy GWA study, we propose to obtain gene expression and methylation data from 100 biopsy specimens obtained from well-characterized chronic pharmacoresistant mTLE+HS patients, who underwent resection of the temporal lobe at the National Hospital for Neurology and Neurosurgery (NHNN) and for whom we already have whole-genotyping data. Individuals will be matched for age, gender and ethnic background with healthy controls from two ongoing whole genome expression and methylation studies at UCL. The integration of gene expression with genetic variability will provide insights into the causal variants and how this may lead to mTLE+HS. In addition, we will investigate an additional biological mechanism, methylation that could alter an individual's susceptibility to mTLE+HS risk. Our interdisciplinary approach will contribute to the understanding of the molecular mechanisms underlying mTLE+HS pathology. In the long term, this understanding will lead to the preventative identification of high-risk patients and the development of novel therapies, aimed at the prevention of seizures and the cognitive impairment suffered by these patients.

Conecta tu I+D

Entra hoy

¿Olvidé mi contraseña?

Financiación

Empresas

CTIs/Universidades

Proyectos

Investigadores