Generation of ultra deep libraries of transcriptional activators for gene therap...
Generation of ultra deep libraries of transcriptional activators for gene therapy
We have generated a novel genetic circuit that, by combining an unusual site-specific recombinase and molecular splicing, allows to functionally diversify modular proteins in-vivo in a highly-directed manner. Applying this method...
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Información proyecto Diverge
Duración del proyecto: 18 meses
Fecha Inicio: 2019-03-06
Fecha Fin: 2020-09-30
Fecha límite de participación
Sin fecha límite de participación.
Descripción del proyecto
We have generated a novel genetic circuit that, by combining an unusual site-specific recombinase and molecular splicing, allows to functionally diversify modular proteins in-vivo in a highly-directed manner. Applying this method to modular transcriptional activators allowed us to generate billions and even trillions of transcription factors variants in-vivo starting from a single base construct. The aim of the DIVERGE PoC project is to to explore the commercial potential of this approach for the isolation of transcriptional activators for human gene activation therapy and to establish a strategy for commercialisation of current and conceivable future implementations of this technology.