Hola,
¿eres nuevo aquí?

Regístrate gratis y conecta tu empresa con financiación pública, partners y proyectos.

Tengo cuenta

Regístrate

Ver video

TargetGBM

Financiado

Cerrado

Generating a targeted brain permeable and stable polymeric nanoparticle for sys...

Generating a targeted brain permeable and stable polymeric nanoparticle for systemic gene delivery to glioblastoma Glioblastoma multiforme (GBM) is the most prevalent deadly brain tumour and is currently incurable. Patients die from recurrent tumours that grow from cells surviving the first round of treatment. This is mainly due to the narrow... ver más

30/06/2021

INSTITUT QUIMIC DE...

161K€

Presupuesto del proyecto: 161K€

Líder del proyecto

INSTITUT QUIMIC DE SARRIA CENTRE D ENSENYAMEN... Educación universitaria asociacion

TRL 4-5 | 50K€

Fecha límite participación Sin fecha límite de participación.

Financiación concedida El organismo H2020 notifico la concesión del proyecto el día 2021-06-30

MSCA-IF-2018: Individual Fellowships

I+D

Cerrada hace 6 años

0% 100% 100%

Información adicional privada

No hay información privada compartida para este proyecto. Habla con el coordinador.

1 Participantes

INSTITUT QUIMIC DE SARRIA CE...

160.93K€ | Lider

Conecta tu I+D

¿Tienes un proyecto y buscas un partner? Gracias a nuestro motor inteligente podemos recomendarte los mejores socios y ponerte en contacto con ellos. Te lo explicamos en este video

Proyectos interesantes

PID2021-124363OA-I00 NANOPARTICULAS CAMUFLADAS CON MEMBRANAS CELULARES PARA TERAP... 157K€ Cerrado

SLaMM Magnetic Solid Lipid Nanoparticles as a Multifunctional Plat... 1M€ Cerrado

FluoNeeD Fluorinated Lipid Nanoparticles for Gene Delivery and Diagno... 212K€ Cerrado

Smart Nanoparticles 4D Brain-Targeting Nanomedicines for Treating Neurodegenerat... 2M€ Cerrado

INC-FPGS-2010-0724 Investigación y desarrollo de una nueva formulación para el... 81K€ Cerrado

CodeSphere CodeSphere Discovering Therapeutic Nanoparticles by Molecu... 150K€ Cerrado

Duración del proyecto: 26 meses Fecha Inicio: 2019-04-29
Fecha Fin: 2021-06-30

Líder del proyecto

INSTITUT QUIMIC DE SARRIA CENTRE D ENSENYAMEN... Educación universitaria asociacion

TRL 4-5 | 50K€

Presupuesto del proyecto 161K€

Fecha límite de participación Sin fecha límite de participación.

Descripción del proyecto Glioblastoma multiforme (GBM) is the most prevalent deadly brain tumour and is currently incurable. Patients die from recurrent tumours that grow from cells surviving the first round of treatment. This is mainly due to the narrow therapeutic window of current drugs and to the low permeability of these drugs across the blood-brain barrier (BBB). Targeted non-viral delivery systems have shown great promise to decrease side effects of therapeutics and to enable the transport across biological barriers. The main objective in this proposal is to generate a dually targeted nanoparticle loaded with mRNA encoding a conditionally toxic protein to treat brain cancer. The nanoparticle will be modified with two ligands: an antibody for targeting tumour cells and a peptide that enables transport across the BBB. In addition, I will develop an acid-labile coating that enhances the stability of the polyplex in blood and is released upon internalization. This coating will present the ligands in a defined orientation using bioorthogonal chemistry, thereby maximising their targeting efficiency. The chemical handles will be introduced using genetic code expansion in the antibody and solid-phase synthesis in the peptide. A variety of formulations will be screened in vitro to evaluate their stability and transfection efficiency, and BBB permeability will be assessed in a human cell-based BBB model. Subsequently, the efficacy of the most promising candidates will be tested in a GBM mouse model. The combination of a polyplex having high transfection efficiency with a sheddable coating and oriented targeting ligands is designed to generate the first efficient non-viral gene delivery system for the systemic treatment of GBM, reaching all tumour cells to provide a more efficient treatment and potentially prevent recurrence.

Conecta tu I+D

Entra hoy

¿Olvidé mi contraseña?

Financiación

Empresas

CTIs/Universidades

Proyectos

Investigadores