FunMagResBeacons
Financiado
Functionalized Magnetic Resonance Beacons for Enhanced Spectroscopy and Imaging
"This project will develop and demonstrate molecular agents called functional magnetic resonance beacons (fMRBs). These will provide a new set of versatile spectroscopic tools for the spatially resolved study of chemistry, biochem...
"This project will develop and demonstrate molecular agents called functional magnetic resonance beacons (fMRBs). These will provide a new set of versatile spectroscopic tools for the spatially resolved study of chemistry, biochemistry, diffusion, flow and percolation inside opaque objects. The fMRB agents support hyperpolarized nuclear spin order, which generates enormously enhanced nuclear magnetic resonance (NMR) signals. The agents are designed to maintain such order for long times (between 5 minutes and several hours) in ambient temperature solution, enabling their transport deep inside opaque objects. The molecules are functionalized, so that they light up"" in an NMR or magnetic resonance imaging (MRI) experiment, upon triggering by specific chemical signals or physical conditions (sensory functionality), and may also to bind to selected molecular targets (binding functionality). One set of proposed realisations possesses lock-and-key functionality, meaning that the hyperpolarized nuclear spin order is locked into a form which is invisible in the NMR spectrometer, but which may be unlocked at any chosen time by applying a suitable radiofrequency pulse sequence. The following molecular moieties are proposed as storage modules: (1) molecular cages, such as functionalized C60 fullerenes, encapsulating noble gas atoms such as 3He; (2) spin clusters supporting long-lived states, such as pairs of 13C or 15N nuclei, in shielded molecular environments. The sensory moieties include tailored peptide sequences, which may be activated by the presence of particular proteases, while binding modules include moieties such as biotin. The agents are designed to be conveniently transportable in a hyperpolarized state. Potential long-term applications include in vivo molecular imaging by MRI.
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Duración del proyecto: 76 meses
Fecha Inicio: 2018-05-15
Fecha Fin: 2024-09-30
Fecha Fin: 2024-09-30
Línea de financiación: concedida
El organismo H2020 notifico la concesión del proyecto el día 2024-09-30
Línea de financiación objetivo
El proyecto se financió a través de la siguiente ayuda:
ERC-2017-ADG:
ERC Advanced Grant
Cerrada
hace 7 años
Presupuesto
El presupuesto total del proyecto asciende a
3M€
Líder del proyecto
UNIVERSITY OF SOUTHAMPTON
No se ha especificado una descripción o un objeto social para esta compañía.
Perfil tecnológico
TRL
4-5
Perfil tecnológico
TRL
4-5
241.00K€ |
Participante