Hola,
¿eres nuevo aquí?

Regístrate gratis y conecta tu empresa con financiación pública, partners y proyectos.

Tengo cuenta

Regístrate

Ver video

AMYGDALA IMAGING

Financiado

Cerrado

Functional in vivo two photon imaging of fear memory traces in identified neuron...

Functional in vivo two photon imaging of fear memory traces in identified neuronal networks of the amygdala Memory formation is one of the most sophisticated and fascinating functions of the nervous system. Our brains remain plastic throughout life and enable us to store and access an amount of information that no computer could cope wi... ver más

31/12/2011

FMI

100K€

Presupuesto del proyecto: 100K€

Líder del proyecto

Novartis Forschungsstiftung No se ha especificado una descripción o un objeto social para esta compañía.

Fecha límite participación Sin fecha límite de participación.

Financiación concedida El organismo FP7 notifico la concesión del proyecto el día 2011-12-31 No tenemos la información de la convocatoria

0% 100% 100%

Información adicional privada

No hay información privada compartida para este proyecto. Habla con el coordinador.

1 Participantes

FMI

100.00K€ | Lider

Conecta tu I+D

¿Tienes un proyecto y buscas un partner? Gracias a nuestro motor inteligente podemos recomendarte los mejores socios y ponerte en contacto con ellos. Te lo explicamos en este video

Proyectos interesantes

STDP-development-AD Neuronal networks dynamics underlying spike timing precision... 181K€ Cerrado

NEUROGOAL Neuronal Coding of Choice and Action Selection during Decisi... 1M€ Cerrado

PrefrontalMap Organization and learning associated dynamics of prefrontal... 2M€ Cerrado

PID2019-110427RB-I00 DECODIFICANDO LA REPRESENTACION NEURONAL DE LA MEMORIA DE R... 109K€ Cerrado

CerebellumTherapy Sensorimotor plasticity in the cerebellar microcircuit and i... 195K€ Cerrado

PID2020-112705RB-I00 DIFERENCIAS DE SEXO EN LA MEMORIA DE MIEDO 284K€ Cerrado

Líder del proyecto

Novartis Forschungsstiftung No se ha especificado una descripción o un objeto social para esta compañía.

Presupuesto del proyecto 100K€

Fecha límite de participación Sin fecha límite de participación.

Descripción del proyecto Memory formation is one of the most sophisticated and fascinating functions of the nervous system. Our brains remain plastic throughout life and enable us to store and access an amount of information that no computer could cope with. While the physiological mechanisms underlying learning have been studied extensively using in vitro preparations, much less is known about how memories are stored at the level of local neuronal circuits in the intact animal. This is an essential question since the dynamic interaction of neurons in their networks is absolutely critical to any form of higher brain function. This proposal outlines a strategy to elucidate how memory formation and extinction alters the activation patterns of local, identified neuronal networks. We will apply a novel and multi-disciplinary approach which combines the recently devised technique of in vivo two-photon calcium imaging using GRIN lenses with established molecular (transgenic mouse lines) and behavioural (fear conditioning) approaches. This will enable us to optically record the activity of many neurons simultaneously and to discern the two major neuronal populations, principal neurons and interneurons, which have opposing roles in the brain. This strategy will be used to study how fear memories manifest themselves in the mouse amygdala. In addition, we will characterise the mechanisms of fear generalisation and extinction. These phenomena are implicated in several human anxiety disorders which afflict an estimated 13% of the population in the EU. Our results will help to better understand the underlying causes of these conditions and potentially reveal novel strategies for pharmaceutical intervention. In addition, this research will define novel concepts on memory storage at the network level, which will be of great interest to the scientific community as well as society at large.

Conecta tu I+D

Entra hoy

¿Olvidé mi contraseña?

Financiación

Empresas

CTIs/Universidades

Proyectos

Investigadores