RESYNC
Financiado
Functional chemical reprogramming of cancer cells to induce antitumor immunity
THE CHALLENGE: Immunotherapy has revolutionized cancer treatment but most patients do not respond due to immune evasion mechanisms, including heterogeneity and lack of tumor antigen presentation. Moreover, these therapies have met...
THE CHALLENGE: Immunotherapy has revolutionized cancer treatment but most patients do not respond due to immune evasion mechanisms, including heterogeneity and lack of tumor antigen presentation. Moreover, these therapies have met limited success in the treatment of solid tumors and are frequently associated with severe adverse effects.RADICAL VISION: The radical vision of the RESYNC consortium is to revolutionize cancer immunotherapy through small-molecule (SM)-based reprogramming of cancer cells into immunogenic (neo)antigen-presenting dendritic cells type 1 (cDC1) to elicit a personalized anti-tumor immunity. Cell reprogramming will be coupled with nanoparticle formulations enabling safe, low cost and efficient systemic targeting of disseminated tumors. The proposed platform will enable breakthrough innovations in the cellular reprogramming-based therapeutics space and have a broad and disruptive effect on the immune-oncology therapeutics scientific field and market. With a complementary consortium, we expect to achieve proof-of-concept for chemical cDC1 reprogramming by the end of the project (2026).IMPACT: This approach will for the first time harness the full potential of cellular reprogramming to induce immunity against tumour antigens with the tractability of systemic delivery of cDC1-inducing SMs. This project will result in next generation platforms for in vivo reprogramming and cell-targeted delivery of SMs with high cell specificity, low price and improved safety. SM-mediated antigen presentation will be combined with immune checkpoint blockade enabling immunotherapy in all patients. Ultimately, this project will set the stage for a new era of personalized, off-the-shelf cancer immunotherapies.
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Duración del proyecto: 35 meses
Fecha Inicio: 2024-01-01
Fecha Fin: 2026-12-31
Fecha Fin: 2026-12-31
Línea de financiación: concedida
El organismo HORIZON EUROPE notifico la concesión del proyecto el día 2024-01-01
Línea de financiación objetivo
El proyecto se financió a través de la siguiente ayuda:
HORIZON-EIC-2023-PATHFINDEROPEN-01-01:
EIC Pathfinder Open
Cerrada
hace 1 año
Presupuesto
El presupuesto total del proyecto asciende a
3M€
Líder del proyecto
LUNDS UNIVERSITET
No se ha especificado una descripción o un objeto social para esta compañía.
Perfil tecnológico
TRL
4-5
Perfil tecnológico
TRL
4-5