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REBORN

Financiado

Full human based multi scale constructs with jammed regenerative pockets for bon...

Full human based multi scale constructs with jammed regenerative pockets for bone engineering Engineered bone tissue has been viewed as a potential alternative to the traditional use of bone grafts, due to their limitless supply and no disease transmission. However, bone tissue engineering practices have not proceeded to c... ver más

31/10/2026

UAveiro

2M€

Presupuesto del proyecto: 2M€

Líder del proyecto

UNIVERSIDADE DE AVEIRO No se ha especificado una descripción o un objeto social para esta compañía.

TRL 4-5

Ver 2 Participantes

Financiación concedida El organismo H2020 notifico la concesión del proyecto el día 2020-09-09

ERC-2019-ADG: ERC Advanced Grant

I+D

Cerrada hace 5 años

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2 Participantes

UAveiro

2.50M€ | Lider

REFRACTARIOS ALFRAN

412.39K€ | Participante

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Duración del proyecto: 73 meses Fecha Inicio: 2020-09-09
Fecha Fin: 2026-10-31

Líder del proyecto

UNIVERSIDADE DE AVEIRO No se ha especificado una descripción o un objeto social para esta compañía.

TRL 4-5

Presupuesto del proyecto 2M€

Descripción del proyecto Engineered bone tissue has been viewed as a potential alternative to the traditional use of bone grafts, due to their limitless supply and no disease transmission. However, bone tissue engineering practices have not proceeded to clinical practice as it was not yet possible to fully recreate the right conditions to produce relevant large vascularized grafts and enabling their in vivo integration and remodelling. REBORN proposes rather unique toolboxes combining bionstructive biomaterials only based on human proteins obtained from the amniotic membrane (AM) and cells from the umbilical/blood cord for the ground-breaking advances of engineering totally time-self-regulated complex 3D devices, able to adjust the cascade of processes leading to faster high-quality and vascularized new bone tissue formation with minimum pre-processing of cells. Proteins from AM will be chemically modified with bioorthogonal clickable moieties enabling their selective association during the fabrication of liquified pockets or hydrogels. Perm-selective AM-protein membranes will be formed at the interface of aqueous-based emulsions to produce liquified pockets confining all necessary ingredients for internal in vitro tissue development to recreate the bone niche including: (i) the correct cells’ ratio, (ii) hydrogel MicroBlocks that will provide geometrical, mechanical and topographic cues to control cellular behaviour and (iii) bioactive soluble factors. Jammed liquified pockets will be assembled into a final desired implantable device, bound by the developed hydrogels, with clinically relevant size, shape and structural integrity, using non-conventional 3D bioprinting processing methodologies or by physical fixation in bioinspired, periosteum-like, regenerative membranes. Advanced techniques will be employed to characterise the new tissue developed in the hybrid devices, from the ultrastructure of the mineral/organic component, including under distinctive dynamic culturing conditions.

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