Hola,
¿eres nuevo aquí?

Regístrate gratis y conecta tu empresa con financiación pública, partners y proyectos.

Tengo cuenta

Regístrate

Ver video

CaNANObinoids

Financiado

From Peripheralized to Cell and Organelle Targeted Medicine The 3rd Generation...

From Peripheralized to Cell and Organelle Targeted Medicine The 3rd Generation of Cannabinoid 1 Receptor Antagonists for the Treatment of Chronic Kidney Disease Clinical experience with globally-acting cannabinoid-1 receptor (CB1R) antagonists revealed the benefits of blocking CB1Rs for the treatment of obesity and diabetes. However, their use is hampered by increased CNS-mediated side ef... ver más

30/09/2021

THE HEBREW UNIVERS...

2M€

Presupuesto del proyecto: 2M€

Líder del proyecto

THE HEBREW UNIVERSITY OF JERUSALEM No se ha especificado una descripción o un objeto social para esta compañía.

TRL 4-5

Fecha límite participación Sin fecha límite de participación.

Ver 2 Participantes

Financiación concedida El organismo H2020 notifico la concesión del proyecto el día 2021-09-30

ERC-StG-2015: ERC Starting Grant

I+D

Cerrada hace 9 años

0% 100% 100%

Información adicional privada

No hay información privada compartida para este proyecto. Habla con el coordinador.

2 Participantes

THE HEBREW UNIVERSITY OF JER...

1.50M€ | Lider

ARCELORMITTAL OLABERRIA-BERG...

871.38K€ | Participante

Conecta tu I+D

¿Tienes un proyecto y buscas un partner? Gracias a nuestro motor inteligente podemos recomendarte los mejores socios y ponerte en contacto con ellos. Te lo explicamos en este video

Proyectos interesantes

RTI2018-095544-B-I00 ABORDAJE DE LAS ENFERMEDADES CRONICAS CON NUEVOS ENFOQUES TE... 157K€ Cerrado

SAF2015-68580-C2-2-R LOS RECEPTORES CB2, GPR55, GPR18 Y LA SEÑALIZACION DEL PPAR-... 145K€ Cerrado

PDC2021-121434-I00 PEPTIDOS COADYUVANTES PARA EVITAR LOS EFECTOS SECUNDARIOS DE... 150K€ Cerrado

SAF2009-12422-C02-01 MAY THE CANNABINOID SYSTEM BE A USEFUL THERAPEUTIC TARGET? I... 266K€ Cerrado

SAF2015-68580-C2-1-R DIANAS EN EL SISTEMA ENDOCANNABINOIDE PARA EL DESARROLLO DE... 303K€ Cerrado

SAF2009-12422-C02-02 HACIA NUEVOS CANNABINOIDES: DISEÑO IN SILICO Y LIGANDOS MULT... 157K€ Cerrado

Duración del proyecto: 66 meses Fecha Inicio: 2016-03-15
Fecha Fin: 2021-09-30

Líder del proyecto

THE HEBREW UNIVERSITY OF JERUSALEM No se ha especificado una descripción o un objeto social para esta compañía.

TRL 4-5

Presupuesto del proyecto 2M€

Fecha límite de participación Sin fecha límite de participación.

Descripción del proyecto Clinical experience with globally-acting cannabinoid-1 receptor (CB1R) antagonists revealed the benefits of blocking CB1Rs for the treatment of obesity and diabetes. However, their use is hampered by increased CNS-mediated side effects. Recently, I have demonstrated that peripherally-restricted CB1R antagonists have the potential to treat the metabolic syndrome without eliciting these adverse effects. While these results are promising and are currently being developed into the clinic, our ability to rationally design CB1R blockers that would target a diseased organ is limited. The current proposal aims to develop and test cell- and organelle-specific CB1R antagonists. To establish this paradigm, I will focus our interest on the kidney, since chronic kidney disease (CKD) is the leading cause of increased morbidity and mortality of patients with diabetes. Our first goal will be to characterize the obligatory role of the renal proximal tubular CB1R in the pathogenesis of diabetic renal complications. Next, we will attempt to link renal proximal CB1R with diabetic mitochondrial dysfunction. Finally, we will develop proximal tubular (cell-specific) and mitochondrial (organelle-specific) CB1R blockers and test their effectiveness in treating CKD. To that end, we will encapsulate CB1R blockers into biocompatible polymeric nanoparticles that will serve as targeted drug delivery systems, via their conjugation to targeting ligands. The implications of this work are far reaching as they will (i) point to renal proximal tubule CB1R as a novel target for CKD; (ii) identify mitochondrial CB1R as a new player in the regulation of proximal tubular cell function, and (iii) eventually become the drug-of-choice in treating diabetic CKD and its comorbidities. Moreover, this work will lead to the development of a novel organ-specific drug delivery system for CB1R blockers, which could be then exploited in other tissues affected by obesity, diabetes and the metabolic syndrome.

Conecta tu I+D

Entra hoy

¿Olvidé mi contraseña?

Financiación

Empresas

CTIs/Universidades

Proyectos

Investigadores