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FLAMIN-GO

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From pathobioLogy to synoviA on chip driving rheuMatoId arthritis to the precis...

From pathobioLogy to synoviA on chip driving rheuMatoId arthritis to the precisioN medicine GOal FLAMIN-GO aims at developing an Organ-on-Chip technology for clinical trials on Rheumatoid Arthritis (RA). In RA, a number of unmet needs still persist particularly related to response/non-response of powerful but expensive drugs.... ver más

30/06/2025

UPO

6M€

Presupuesto del proyecto: 6M€

Líder del proyecto

UNIVERSITA DEGLI STUDI DEL PIEMONTE ORIENTALE... No se ha especificado una descripción o un objeto social para esta compañía.

TRL 4-5

Fecha límite participación Sin fecha límite de participación.

Ver 14 Participantes

Financiación concedida El organismo H2020 notifico la concesión del proyecto el día 2020-11-06

DT-NMBP-23-2020: Next generation organ-on-chip (RIA-... Specific Challenge:‘Organ-on-Chip’ (OoC) is a promising technology for achieving more effective in-v...

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14 Participantes

UPO

908.70K€ | Lider

ZNANOST NA CESTI ZAVOD ZA PR...

60.25K€ | Participante

TRUSTECH SRL

439.38K€ | Participante

STANDARD BIOTOOLS FRANCE SAR...

755.13K€ | Participante

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Duración del proyecto: 55 meses Fecha Inicio: 2020-11-06
Fecha Fin: 2025-06-30

Líder del proyecto

UNIVERSITA DEGLI STUDI DEL PIEMONTE ORIENTALE... No se ha especificado una descripción o un objeto social para esta compañía.

TRL 4-5

Presupuesto del proyecto 6M€

Fecha límite de participación Sin fecha límite de participación.

Descripción del proyecto FLAMIN-GO aims at developing an Organ-on-Chip technology for clinical trials on Rheumatoid Arthritis (RA). In RA, a number of unmet needs still persist particularly related to response/non-response of powerful but expensive drugs. Conventional clinical trials may address part of these challenges, but are time consuming, expensive and ethically ethically doubtful as part of the patients still fail to achieve disease benefits. Thus, the rheumatology community has a need for an alternative strategy that can deliver innovative trials. FLAMIN-GO develops a personalized next-generation synovia-on-chip, that, by effectively mimicking the complexity of RA joint, will allow performing personalized clinical trials-on-chip. The solution will be based on design and fabrication of a multi-compartment microfluidic platform, for 3D culturing and perfusion of all the disease-relevant joint tissues. It focuses on synovia and synovial fluid, which are the pathogenetic targeted tissues, but including immune system, who sustain the disease, and cartilage and bone which are the end damaged tissues, leading to permanent disability. Starting from individual patient biopsies, this model seeks to replicate RA joints, thus allowing to test and allocate the best on-market drug for that patient in 1-2 months starting form biopsy. When validated, the platform will also be a turning point for i) pharma by enabling screening of new drugs reducing costs, time, and animal testing and for ii) translational research for identification of new biomarkers or therapeutic targets. FLAMIN-GO consortium features a strong, well-balanced composition of hospital, academia and industry partners, who cover with complementary expertise the whole value chain. It gathers experts in the fields of rheumatology, material science, tissue engineering, nanotechnology, cell biology and 3D modelling, in a cohesive, transdisciplinary, multi-sectorial approach taking on the challenge to drive RA personalized care.

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