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OPATHY

Financiado

From Omics to Patient Improving Diagnostics of Pathogenic Yeasts

OPATHY is an innovative translational research training network that will explore the potential of omics technologies, including genomics, transcriptomics and proteomics, to study the interactions of yeasts that cause disease to h... ver más

31/08/2019

FUNDACIO PRIVADA C...

3M€

Presupuesto del proyecto: 3M€

Líder del proyecto

FUNDACIO PRIVADA CENTRE DE REGULACIO GENOMICA Otras actividades deportivas asociacion

TRL 4-5 | 50K€

Ver 11 Participantes

Financiación concedida El organismo H2020 notifico la concesión del proyecto el día 2019-08-31

MSCA-ITN-2014-ETN: Marie Skłodowska-Curie Innovative T... Scope:European Training Networks (ETN)

I+D

Cerrada hace 10 años

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11 Participantes

FUNDACIO PRIVADA CENTRE DE R...

495.75K€ | Lider

MISTRAL BONSAI

210.96K€ | Participante

UGent

250.56K€ | Participante

BIOTECH VANA

247.87K€ | Participante

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Duración del proyecto: 48 meses Fecha Inicio: 2015-08-18
Fecha Fin: 2019-08-31

Líder del proyecto

FUNDACIO PRIVADA CENTRE DE REGULACIO GENOMICA Otras actividades deportivas asociacion

TRL 4-5 | 50K€

Presupuesto del proyecto 3M€

Descripción del proyecto OPATHY is an innovative translational research training network that will explore the potential of omics technologies, including genomics, transcriptomics and proteomics, to study the interactions of yeasts that cause disease to humans (e.g. Candida and Cryptococcus sp.) with their host, and to develop new diagnostic tools to monitor yeast infections in the clinic. Today, these infections are poorly understood, difficult to diagnose, and are becoming increasingly frequent and serious, affecting over 300 million people worldwide. OPATHY will exploit omics technologies to investigate host-pathogen interactions during yeast infection and colonization with a primary focus on their potential to develop innovative diagnostics tools to improve health care. For this proteomics, transcriptomics and genomics measurements of strains and infections will be integrated with state of the art computational analyses to identify novel biomarkers able to determine the infection stage, the infective pathogen, and the potential resistance traits. This knowledge will drive the development of diagnostic tools based on the detection of specific DNA sequences (by PCR) or antibodies (by Elisa or proteomics). These tools will be validated in a clinical study of key patient cohorts. The participation of two clinical centers and four companies is of paramount importance for the network to provide an integrative and transversal research and training environment. Importantly, the methodologies and approaches of OPATHY can be easily extended to the study and identification of other human, animal and plant microbial pathogens, or the tracing of relevant industrial organisms. Grounded on solid individual research projects, OPATHY will train Early Stage Researchers in several scientific technologies and fields and transferable skills, to boost their careers as innovative and creative researchers.

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