Innovating Works

PROTOEYE

Financiado
From light detection to vision revealing diversity of function of simple eyes...
From light detection to vision revealing diversity of function of simple eyes and light responsive behaviours to enlighten eye evolution Complex animal eyes evolved many times independently from simpler forms. As already suggested by Darwin, the path to vision may have led from non-directional to directional light sensing and then to low-resolution spatial vision.... Complex animal eyes evolved many times independently from simpler forms. As already suggested by Darwin, the path to vision may have led from non-directional to directional light sensing and then to low-resolution spatial vision. Simple eyes in extant animals show a remarkable diversity of form and function and may hold the key to the origin of eyes and vision. We do not know why this diversity evolved when the organisms all respond to the same physical cue. Although we have a detailed molecular-centric view of eye evolution across animals, we lack corresponding knowledge of the physical mechanics and neuronal circuits coordinating the responses. PROTOEYE will study the diversity of simple non-visual and visual eyes and map the phase space of light-guided behaviours across animals. This will inform general principles of sensory system evolution and our understanding of the origin and evolution of eyes and visual circuits. The project will build on our long-term expertise in neural circuits and mechanistic photo-biology. We will study a range of aquatic invertebrates with distinct behavioural strategies, unified by the presence of simple eyes and non-visual photoreceptors. Instead of looking at eyes in isolation, we will investigate light responses from a whole-organism perspective focusing on circuits, behaviour and the biophysics of motion. In order to obtain entire neuronal circuits driving photic behaviours, we will use whole-body serial electron microscopy and connectomics. With laser ablation, we will explore strategies of light-seeking or light-avoidance behaviours. In high-throughput behavioural assays we will test navigation strategies and sensitivities to different wavelengths. With high-speed imaging and flow tracing, we will investigate how animal movement is shaped by light. This comparative and multi-disciplinary project will chart the functional diversity of simple eyes and provide a new framework for understanding the evolution of animal vision. ver más
31/12/2026
UHEI
3M€
Duración del proyecto: 65 meses Fecha Inicio: 2021-07-28
Fecha Fin: 2026-12-31

Línea de financiación: concedida

El organismo H2020 notifico la concesión del proyecto el día 2021-07-28
Línea de financiación objetivo El proyecto se financió a través de la siguiente ayuda:
ERC-2020-ADG: ERC ADVANCED GRANT
Cerrada hace 4 años
Presupuesto El presupuesto total del proyecto asciende a 3M€
Líder del proyecto
RUPRECHTKARLSUNIVERSITAET HEIDELBERG No se ha especificado una descripción o un objeto social para esta compañía.
Perfil tecnológico TRL 4-5