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From endosymbiont to organelle: Mechanisms of cellular integration between Pauli...

From endosymbiont to organelle: Mechanisms of cellular integration between Paulinella and its chromatophores The endosymbiotic integration of cyanobacteria within Eukaryotes was one of the pivotal evolutionary transitions. This transition, however, is difficult to study because modern plastids represent highly derived ‘end-states’ and ar... ver más

30/04/2025

UDUS

174K€

Presupuesto del proyecto: 174K€

Líder del proyecto

HEINRICH-HEINE-UNIVERSITAET DUESSELDORF No se ha especificado una descripción o un objeto social para esta compañía.

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Financiación concedida El organismo HORIZON EUROPE notifico la concesión del proyecto el día 2022-06-17

Línea de financiación objetivo El proyecto se financió a través de la siguiente ayuda:

HORIZON-MSCA-2021-PF-01-01: MSCA Postdoctoral Fellowships 2021

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Duración del proyecto: 34 meses Fecha Inicio: 2022-06-17
Fecha Fin: 2025-04-30

Presupuesto del proyecto 174K€

Descripción del proyecto The endosymbiotic integration of cyanobacteria within Eukaryotes was one of the pivotal evolutionary transitions. This transition, however, is difficult to study because modern plastids represent highly derived ‘end-states’ and are not transitionary; we know, therefore, very little about the mechanisms involved. Primary plastid endosymbiosis has occurred only twice: once in the ancestor of Archaeplastida and once independently in the amoeba Paulinella. Each Paulinella cell houses two chromatophores, which are photosynthetic units that resemble plastids yet are more closely related to cyanobacteria. Genetic studies of Paulinella and its cyanobacterial-derived chromatophores revealed it is an intermediary in the evolution of a photosynthetic organelle. Studying Paulinella, therefore, offers unique insight into the mechanistic processes of plastid integration. Despite our growing genetic knowledge, little is known about the integration of the chromatophores in terms of their cellular physiology. In this proposal, I aim to address this by exploring this unique association at the metabolomic, transcriptomic and proteomic levels. First, I plan to characterise the metabolites exchanged between the cell and chromatophores using an isotope-labelling metabolic experiment (objective 1). Second, I will study the coordinated light response of the nucleus and chromatophore at the transcriptional, metabolic, and protein level (objective 2). Finally, I will perform a long-term evolution experiment to expose Paulinella chromatophora to high and fluctuating light regimes to test whether its light regulation can evolve in response to different light environments (objective 3). The outcomes will provide insight into the molecular mechanisms that facilitate the integration of the chromatophores within Paulinella. This in turn will aid our understanding of the acquisition and integration of plastids, and the evolutionary trajectory from endosymbiont to organelle.

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