Hola,
¿eres nuevo aquí?

Regístrate gratis y conecta tu empresa con financiación pública, partners y proyectos.

Tengo cuenta

Regístrate

Ver video

4DBIOSERS

Financiado

Cerrado

Four Dimensional Monitoring of Tumour Growth by Surface Enhanced Raman Scatterin...

Four Dimensional Monitoring of Tumour Growth by Surface Enhanced Raman Scattering Optical bioimaging is limited by visible light penetration depth and stability of fluorescent dyes over extended periods of time. Surface enhanced Raman scattering (SERS) offers the possibility to overcome these drawbacks, through... ver más

30/09/2024

ASOC CENTRO DE INV...

2M€

Presupuesto del proyecto: 2M€

Líder del proyecto

ASOC CENTRO DE INVESTIGACION COOP EN BIO No se ha especificado una descripción o un objeto social para esta compañía.

TRL 3-4 | 6M€

Fecha límite participación Sin fecha límite de participación.

Ver 2 Participantes

Financiación concedida El organismo H2020 notifico la concesión del proyecto el día 2024-09-30

ERC-2017-ADG: ERC Advanced Grant

I+D

Cerrada hace 7 años

0% 100% 100%

Información adicional privada

No hay información privada compartida para este proyecto. Habla con el coordinador.

2 Participantes

ASOC CENTRO DE INVESTIGACION...

2.41M€ | Lider

INGETEAM POWER TECHNOLOGY

774.18K€ | Participante

Conecta tu I+D

¿Tienes un proyecto y buscas un partner? Gracias a nuestro motor inteligente podemos recomendarte los mejores socios y ponerte en contacto con ellos. Te lo explicamos en este video

Proyectos interesantes

GSYNCOR Graphene syncronized coherent Raman scattering laser and mic... 150K€ Cerrado

VIBRA Very fast Imaging by Broadband coherent RAman 2M€ Cerrado

N-SHEAD Nanoarrays Self assembled Hotspots for Enhanced Analyte Det... 183K€ Cerrado

Raman Gold Nanoprisms as Raman Signal Amplifiers for Bioimaging of... 255K€ Cerrado

sCiSsoRS Backscattering coherent Stokes Raman scattering (sCiSsoRS) f... 2M€ Cerrado

RISH Imaging of multiple mRNA targets using SERS nanoparticle lab... 159K€ Cerrado

Duración del proyecto: 76 meses Fecha Inicio: 2018-05-25
Fecha Fin: 2024-09-30

Líder del proyecto

ASOC CENTRO DE INVESTIGACION COOP EN BIO No se ha especificado una descripción o un objeto social para esta compañía.

TRL 3-4 | 6M€

Presupuesto del proyecto 2M€

Fecha límite de participación Sin fecha límite de participación.

Descripción del proyecto Optical bioimaging is limited by visible light penetration depth and stability of fluorescent dyes over extended periods of time. Surface enhanced Raman scattering (SERS) offers the possibility to overcome these drawbacks, through SERS-encoded nanoparticle tags, which can be excited with near-IR light (within the biological transparency window), providing high intensity, stable, multiplexed signals. SERS can also be used to monitor relevant bioanalytes within cells and tissues, during the development of diseases, such as tumours. In 4DBIOSERS we shall combine both capabilities of SERS, to go well beyond the current state of the art, by building three-dimensional scaffolds that support tissue (tumour) growth within a controlled environment, so that not only the fate of each (SERS-labelled) cell within the tumour can be monitored in real time (thus adding a fourth dimension to SERS bioimaging), but also recording the release of tumour metabolites and other indicators of cellular activity. Although 4DBIOSERS can be applied to a variety of diseases, we shall focus on cancer, melanoma and breast cancer in particular, as these are readily accessible by optical methods. We aim at acquiring a better understanding of tumour growth and dynamics, while avoiding animal experimentation. 3D printing will be used to generate hybrid scaffolds where tumour and healthy cells will be co-incubated to simulate a more realistic environment, thus going well beyond the potential of 2D cell cultures. Each cell type will be encoded with ultra-bright SERS tags, so that real-time monitoring can be achieved by confocal SERS microscopy. Tumour development will be correlated with simultaneous detection of various cancer biomarkers, during standard conditions and upon addition of selected drugs. The scope of 4DBIOSERS is multidisciplinary, as it involves the design of high-end nanocomposites, development of 3D cell culture models and optimization of emerging SERS tomography methods.

Conecta tu I+D

Entra hoy

¿Olvidé mi contraseña?

Financiación

Empresas

CTIs/Universidades

Proyectos

Investigadores