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DevBoundaries

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Formation of tissue boundaries during zebrafish embryogenesis

During animal development, boundaries need to be reliably established between cell types to guarantee the physical and functional integrity of tissues. This process requires delicate orchestration of cell proliferation, differenti... ver más

31/08/2024

UNIVERSITAT BASEL

191K€

Presupuesto del proyecto: 191K€

Líder del proyecto

UNIVERSITAT BASEL No se ha especificado una descripción o un objeto social para esta compañía.

TRL 4-5

Fecha límite participación Sin fecha límite de participación.

Financiación concedida El organismo H2020 notifico la concesión del proyecto el día 2024-08-31

MSCA-IF-2020: Individual Fellowships

I+D

Cerrada hace 4 años

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1 Participantes

UNIVERSITAT BASEL

191.15K€ | Lider

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Duración del proyecto: 40 meses Fecha Inicio: 2021-04-07
Fecha Fin: 2024-08-31

Líder del proyecto

UNIVERSITAT BASEL No se ha especificado una descripción o un objeto social para esta compañía.

TRL 4-5

Presupuesto del proyecto 191K€

Fecha límite de participación Sin fecha límite de participación.

Descripción del proyecto During animal development, boundaries need to be reliably established between cell types to guarantee the physical and functional integrity of tissues. This process requires delicate orchestration of cell proliferation, differentiation and migration, and defects in tissue boundary formation are often linked with abnormal cell behaviours in diseases. Genetic programs involved in cell signalling and cell sorting across tissue boundaries have been previously identified, yet we still lack a systematic understanding of the mechanisms underlying boundary formation, because it has been challenging to analyse the coordination of gene expression, cell lineages and cell movement in space and time. In this study, I will probe the in vivo mechanisms of tissue boundary formation using the zebrafish embryonic shield as a model system. The embryonic shield in zebrafish embryos is an evolutionarily conserved organizer structure that is critical for setting up the overall body plan of the embryos. The shield region contains overlapping progenitor cells that give rise to various tissue structures whose boundaries form and sharpen during gastrulation. However, the formation of shield progenitor cells into compartmentalized tissues has been a process that is poorly characterized, and the molecular and biophysical mechanisms that coordinate cell differentiation and morphogenesis to establish tissue boundaries remain elusive. I will utilize multi-disciplinary approaches that combine live imaging, spatial transcriptomics and genetic manipulation to determine how shield cells differentiate and generate tissue boundaries. I anticipate identifying cellular and genetic mechanisms controlling boundary formation, and provide a comprehensive and dynamic atlas detailing cell lineages, cell movement and gene expression of early embryogenesis in vertebrates.

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