Hola,
¿eres nuevo aquí?

Registrate y conecta tu empresa con financiación pública, partners y proyectos.

Fields4CAT

Financiado

Force Fields in Redox Enzymatic Catalysis

Fields4CAT aims to identify the nature and directionality of the driving forces in a redox enzyme that govern the catalytic chemical process. Industrial bio-manufacturing is one of the pillars of today’s world economy making its w... ver más

28/02/2026

KINGS COLLEGE LOND...

2M€

Presupuesto del proyecto: 2M€

Líder del proyecto

KINGS COLLEGE LONDON No se ha especificado una descripción o un objeto social para esta compañía.

TRL 4-5

Ver 3 Participantes

Financiación concedida El organismo H2020 notifico la concesión del proyecto el día 2018-06-28

Línea de financiación objetivo El proyecto se financió a través de la siguiente ayuda:

ERC-2017-COG: ERC Consolidator Grant

I+D

Cerrada hace 7 años

0% 100%

3 Participantes

KINGS COLLEGE LONDON

2.00M€ | Lider

GAS GAS

302.82K€ | Participante

N.D. | Participante

Proyectos interesantes

CTQ2015-63563-R DESARROLLO DE BIOCATALIZADORES PARA LA FORMACION DE ENLACES... 100K€ Cerrado

TED2021-130803B-I00 IDENTIFICACION Y APLICACIONES SINTETICAS DE NUEVOS BIOCATALI... 191K€ Cerrado

CTQ2013-44153-P BIOTRANSFORMACIONES EN LA SINTESIS QUIMICA DE MOLECULAS ORGA... 139K€ Cerrado

BIO2015-66426-R INGENIERIA Y EVOLUCION DE ENZIMAS DE NOVO CON ACTIVIDADES NO... 399K€ Cerrado

W-BioCat TUNGSTEN BIOCATALYSIS – HEAVY METAL ENZYMES FOR SUSTAINABLE... 2M€ Cerrado

GREASEDLIGHTNING Enzymatic chemistry acting on alkyl chains 2M€ Cerrado

Últimas noticias

27-11-2024: Videojuegos y creaci... Se abre la línea de ayuda pública: Ayudas para la promoción del sector del videojuego, del pódcast y otras formas de creación digital

27-11-2024: DGIPYME En las últimas 48 horas el Organismo DGIPYME ha otorgado 1 concesiones

27-11-2024: FUNDACION-EOI En las últimas 48 horas el Organismo FUNDACION EOI ha otorgado 2 concesiones

Duración del proyecto: 92 meses Fecha Inicio: 2018-06-28
Fecha Fin: 2026-02-28

Líder del proyecto

KINGS COLLEGE LONDON

TRL 4-5

Presupuesto del proyecto 2M€

Descripción del proyecto Fields4CAT aims to identify the nature and directionality of the driving forces in a redox enzyme that govern the catalytic chemical process. Industrial bio-manufacturing is one of the pillars of today’s world economy making its way to a sustainable development. Redox enzymes catalyze the most demanding chemical reactions under mild conditions, such as the oxy-functionalization of non-activated hydrocarbons, which usually requires harsh reaction conditions. Enzyme Biotechnology has greatly progressed thanks to rational mutagenesis schemes that draw upon the static X-ray structural information. The high complexity of enzymatic catalysis has, however, hampered its development because a single point mutation near the active site can affect several relevant parameters at the same time, obscuring the interpretation and constraining the rational design of technological biocatalysts. Fields4CAT proposes dissecting the relevant forces exerted over an individual catalytic active site in its wild-type state, and then using the resulting forces map to design enzyme/metal platforms with enhanced capabilities. To this aim, it develops in 3 blocks organized in a step-wise fashion: (i) block 1 sets up a electrochemical multi-stimuli single-protein toolbox (Ec-SPT) with capabilities to trap individual proteins in a nanoscale tunnelling junction and subject them to a variety of force stimuli, i.e. mechanical, electrostatic and magnetic. (ii) Block 2 designs the chemical electrical plugs that will specifically connect the enzyme to the junction electrodes with precise controlled orientation. (iii) Block 3 characterizes the single-protein electrical signatures of the enzyme activity and quantifies the catalytic effect of the different force stimuli along the vertical junction axis. Fields4CAT will identify new guidelines to bioengineer a redox enzyme/metal platform with tuned catalytic activity, bringing about new breakthroughs in the future of Bio-Catalysis.

Conecta tu I+D

Entra hoy

Financiación

Empresas

CTIs/Universidades

Proyectos

Investigadores