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StreamlineValve

Financiado

Flow Controlled Prosthetic Heart Valves

Prosthetic Heart Valves (HV), both biological (BHV) and mechanical (MHV), have improved the survival rate and the quality of life of valvular heart-disease patients over the last six decades. While BHVs, taken from animal tissue,... ver más

31/08/2025

TECHNION ISRAEL I...

150K€

Presupuesto del proyecto: 150K€

Líder del proyecto

TECHNION ISRAEL INSTITUTE OF TECHNOLOGY No se ha especificado una descripción o un objeto social para esta compañía.

TRL 4-5

Financiación concedida El organismo HORIZON EUROPE notifico la concesión del proyecto el día 2024-02-05

ERC-2023-POC: ERC PROOF OF CONCEPT GRANTS Objective:Objectives:The ERC Proof of Concept Grants aim at facilitating exploration of the commerci...

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1 Participantes

TECHNION ISRAEL INSTITUTE O...

150.00K€ | Lider

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Duración del proyecto: 18 meses Fecha Inicio: 2024-02-05
Fecha Fin: 2025-08-31

Líder del proyecto

TECHNION ISRAEL INSTITUTE OF TECHNOLOGY No se ha especificado una descripción o un objeto social para esta compañía.

TRL 4-5

Presupuesto del proyecto 150K€

Descripción del proyecto Prosthetic Heart Valves (HV), both biological (BHV) and mechanical (MHV), have improved the survival rate and the quality of life of valvular heart-disease patients over the last six decades. While BHVs, taken from animal tissue, show improved hemodynamics, their durability is limited, whereas MHVs can last a patient's entire lifetime but require lifetime anticoagulation medication to reduce thrombotic complications. Future Polymeric HVs (PHV) hold the potential for enhanced durability compared to BHVs, while potentially avoiding the necessity for anticoagulation therapy that MHVs demand. However, the problem of flow-related thrombosis in PHVs remains a critical challenge. Generally, flow-related thrombosis complications can be avoided by altering the flow field around the PHV, such as reducing vortices and circulatory hemodynamic structures as well as decreasing shear stresses which can lead to platelet activation. Inspired by passive flow control in nature and in the aerodynamics industry, where manipulation of fluid flow via a small configuration change provides large engineering benefits in swimming or flying, we aim to use a flow control strategy to optimize blood flow through PHVs. More specifically, in StreamlineValve, we present a new, patented, PHV that is designed to alter the flow field around the valve in a manner that reduces the primary factors contributing to coagulation on PHVs. We have already successfully demonstrated this concept in vitro in a modified MHV. In this PoC, we propose to extend this to the future of prosthetic valves via a flow controlled PHV that can be implanted via a simple transcatheter procedure avoiding undesired surgical procedures. Altogether, StreamlineValve represents a paradigm shift in the realm of prosthetic HVs, offering the potential to enhance valve longevity, quality of life, and patient safety.

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