Hola,
¿eres nuevo aquí?

Regístrate gratis y conecta tu empresa con financiación pública, partners y proyectos.

Tengo cuenta

Regístrate

Ver video

FLINDIP

Financiado

Cerrado

Fitness landscape of intrinsically disordered proteins

Mapping genotype to phenotype is a key problem of protein physics, evolutionary biology, biotechnology and medical genetics. In this project, we plan to focus on intrinsically disordered proteins, a large group of proteins whose g... ver más

10/12/2022

IMPERIAL COLLEGE O...

213K€

Presupuesto del proyecto: 213K€

Líder del proyecto

IMPERIAL COLLEGE OF SCIENCE TECHNOLOGY AND ME... No se ha especificado una descripción o un objeto social para esta compañía.

TRL 4-5

Fecha límite participación Sin fecha límite de participación.

Financiación concedida El organismo H2020 notifico la concesión del proyecto el día 2022-12-10

MSCA-IF-2019: Individual Fellowships

I+D

Cerrada hace 5 años

0% 100%

Información adicional privada

No hay información privada compartida para este proyecto. Habla con el coordinador.

1 Participantes

IMPERIAL COLLEGE OF SCIENCE...

212.93K€ | Lider

Conecta tu I+D

¿Tienes un proyecto y buscas un partner? Gracias a nuestro motor inteligente podemos recomendarte los mejores socios y ponerte en contacto con ellos. Te lo explicamos en este video

Proyectos interesantes

evoDISFOLD Decoding Coupled Folding and Binding via Single Molecule cha... 175K€ Cerrado

IDPro Intrinsically disordered proteins in health and disease: mec... Cerrado

RTI2018-096246-B-I00 INTEGRANDO LAS MODIFICACIONES POSTRADUCCIONALES ESPECIFICAS... 121K€ Cerrado

IdrSeq Discovery and characterization of functional disordered regi... 2M€ Cerrado

CTQ2012-33324 DESCRIPCION DE PROTEINAS INTRINSECAMENTE DESORDENADAS MEDIAN... 25K€ Cerrado

PID2021-127503OB-I00 EXPLORANDO "METAMORFISMO" EN PROTEINAS MULTIFUNCIONALES. 151K€ Cerrado

Duración del proyecto: 32 meses Fecha Inicio: 2020-04-09
Fecha Fin: 2022-12-10

Líder del proyecto

IMPERIAL COLLEGE OF SCIENCE TECHNOLOGY AND ME... No se ha especificado una descripción o un objeto social para esta compañía.

TRL 4-5

Presupuesto del proyecto 213K€

Fecha límite de participación Sin fecha límite de participación.

Descripción del proyecto Mapping genotype to phenotype is a key problem of protein physics, evolutionary biology, biotechnology and medical genetics. In this project, we plan to focus on intrinsically disordered proteins, a large group of proteins whose genotype-phenotype connection is poorly understood. Such proteins do not adopt a unique native structure. Instead, they explore numerous conformations depending on external conditions. Recent bioinformatic analyses show that up to 15% of all proteins are intrinsically disordered. The critical role of intrinsically disordered proteins in cellular functions and in the onset of pathological conditions generated significant interest for their study. Much effort has been devoted to map the effects of particular mutations on protein functionality. However, no attempt to systematically study the genotype-to-phenotype link in intrinsically disordered proteins has been made. Obtaining such information is essential for sharpening theoretical models of protein folding and molecular evolution, as well as for de novo design of intrinsically disordered proteins with improved activities. The aim of this project is to experimentally measure and analyse, for the first time, the genotype-to-phenotype connection for several intrinsically disordered proteins by deep mutational scanning. We plan to focus on tardigrade proteins which are essential for their ability to survive complete desiccation. We plan to generate libraries of cells expressing hundreds of thousands of variants of these proteins and to perform competition assays to measure functionality of every variant in the library. We will then use a variety of approaches to analyse the dataset, including machine-learning algorithms to model the fitness of variants and to design new functional intrinsically disordered proteins.

Conecta tu I+D

Entra hoy

¿Olvidé mi contraseña?

Financiación

Empresas

CTIs/Universidades

Proyectos

Investigadores