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CellFish

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Exploring the mechanisms of long term tumour evolution and genomic instability i...

Exploring the mechanisms of long term tumour evolution and genomic instability in marine transmissible cancers Cancers are proliferative outgrowths of abnormal cells driven by a selfish evolutionary programme. Most cancers arise from and remain within the bodies of their respective host individuals. Rarely, however, cancers may escape thei... ver más

31/12/2029

THE CHANCELLOR MAS...

2M€

Presupuesto del proyecto: 2M€

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THE CHANCELLOR MASTERS AND SCHOLARS OF THE UN... No se ha especificado una descripción o un objeto social para esta compañía.

TRL 4-5

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Financiación concedida El organismo HORIZON EUROPE notifico la concesión del proyecto el día 2024-09-23

ERC-2024-STG: ERC STARTING GRANTS Scope:Objectives

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THE CHANCELLOR MASTERS AND S...

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Duración del proyecto: 63 meses Fecha Inicio: 2024-09-23
Fecha Fin: 2029-12-31

Líder del proyecto

THE CHANCELLOR MASTERS AND SCHOLARS OF THE UN... No se ha especificado una descripción o un objeto social para esta compañía.

TRL 4-5

Presupuesto del proyecto 2M€

Fecha límite de participación Sin fecha límite de participación.

Descripción del proyecto Cancers are proliferative outgrowths of abnormal cells driven by a selfish evolutionary programme. Most cancers arise from and remain within the bodies of their respective host individuals. Rarely, however, cancers may escape their hosts to become ‘transmissible cancers’, infectious cell lineages that spread between individuals by direct transfer of cancer cells. As parasitic cancers capable of surviving for millennia, transmissible cancers offer a unique model for exploring how mutation, selection and cellular processes mould and constrain selfish tumour evolution. Marine bivalves (shellfish including clams, mussels and cockles) are affected by at least 10 transmissible cancers, which spread via waterborne cell transfer. The recurrent emergence of long-lived cancers in shellfish provides a valuable resource for comparative studies aiming to probe the basic mechanisms of tumour evolution, including extreme genomic instability. Yet, the evolutionary histories of these cancers are poorly understood. My vision is to elucidate the origins and evolution of marine transmissible cancers by conducting a large-scale comparative genomic study of these cancers. My aims are to: 1. Understand how transmissible cancers arise, mutate and spread under the sea 2. Identify the mechanisms and consequences of genomic instability in transmissible cancers. My research approach will involve: - Extensive tumour sampling across continents - Generation of high-quality bivalve genome assemblies - Application of state-of-the-art technologies, including laser microdissection and single-cell sequencing, to hundreds of tumours - Development of specialised methods for comparative cancer genome analysis. The intrinsic heterogeneity and short lifespans of most cancers may obscure their underlying biological patterns. By examining the convergent evolution of 10 long-lived cancers through a comparative-genomics lens, I intend to deliver fundamental insights into cancer biology and evolution.

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