Hola,
¿eres nuevo aquí?

Regístrate gratis y conecta tu empresa con financiación pública, partners y proyectos.

Tengo cuenta

Regístrate

Ver video

EXPERIMENTAL

Financiado

EXploring Photoinduced Enzyme pRomIscuity in the Glucose-Methanol-Choline oxidor...

EXploring Photoinduced Enzyme pRomIscuity in the Glucose-Methanol-Choline oxidoreductase family to dEvelop New phoTocAtaLysts Photoenzymes are rare biocatalysts that use the energy contained in photons to perform chemical reactions. To date, only one natural photocatalyst is known to have biotechnological applications; the Fatty Acid Photodecarboxylase (... ver más

14/08/2025

CEA

300K€

Presupuesto del proyecto: 300K€

Líder del proyecto

COMMISSARIAT A L ENERGIE ATOMIQUE ET AUX ENER... No se ha especificado una descripción o un objeto social para esta compañía.

TRL 4-5

Ver 3 Participantes

Financiación concedida El organismo HORIZON EUROPE notifico la concesión del proyecto el día 2022-06-14

HORIZON-MSCA-2021-PF-01-01: MSCA Postdoctoral Fellowships 2021 ExpectedOutcome:

I+D

Cerrada hace 3 años

0% 100%

3 Participantes

CEA

300.44K€ | Lider

TRUSTEES OF PRINCETON UNIVER...

PRINCETON

N.D. | Participante

Conecta tu I+D

¿Tienes un proyecto y buscas un partner? Gracias a nuestro motor inteligente podemos recomendarte los mejores socios y ponerte en contacto con ellos. Te lo explicamos en este video

Proyectos interesantes

BFU2017-92223-EXP VISUALIZACION DE ESTADOS DE TRANSICION EN ENZIMAS MEDIANTE P... 48K€ Cerrado

PID2021-126799NB-I00 RACIONALIZACION DE LOS FACTORES QUE REGULAN LA TRANSFERENCIA... 85K€ Cerrado

BIO2014-59741-R MODULACION ENZIMATICA DE LAS PROPIEDADES CATALITICAS DE LOS... 182K€ Cerrado

PID2020-116261GB-I00 APLICACIONES BIOTECNOLOGICAS DE CRISTALES PROTEICOS 127K€ Cerrado

CTQ2011-28390 INTERRUPTORES SUPRAMOLECULARES EN BASE DE COMPLEJOS ANFITRIO... 68K€ Cerrado

GREAM Breakthrough a glycyl radical enzyme long range activation m... 212K€ Cerrado

Duración del proyecto: 38 meses Fecha Inicio: 2022-06-14
Fecha Fin: 2025-08-14

Líder del proyecto

COMMISSARIAT A L ENERGIE ATOMIQUE ET AUX ENER... No se ha especificado una descripción o un objeto social para esta compañía.

TRL 4-5

Presupuesto del proyecto 300K€

Descripción del proyecto Photoenzymes are rare biocatalysts that use the energy contained in photons to perform chemical reactions. To date, only one natural photocatalyst is known to have biotechnological applications; the Fatty Acid Photodecarboxylase (FAP), allowing the production of hydrocarbons from fatty acids. FAP belongs to a superfamily of enzymes called Glucose Methanol oxidoreductases (GMCox). Still, the FAP group is the only one known to perform photochemistry despite the high degree of structural similarity and presence of a photosensitive cofactor, Flavine Adenine Dinucleotide (FAD), in all GMCox. We reason that the GMCox family could have a latent photochemical function, and we would like to exploit it. Therefore, the objective of this project is to EXplore Photoinduced Enzyme pRomIscuity in the Glucose-Methanol-Choline oxidoreductase family to dEvelop New phoTocAtaLysts (EXPERIMENTAL). To this end, we will first test the photoinduced substrate promiscuity with different GMCox using an accelerated serendipity approach. In a second step, we will optimize the newly discovered photoenzymatic activity by directed evolution. Finally, the enzymatic mechanism will be characterized using different biophysics approaches, ranging from time-resolved spectroscopy to serial femtosecond crystallography. This project is inherently interdisciplinary, combining chemistry, biochemistry and biophysics to develop new photocatalysts for biotechnological purposes. For fundamental research these new photoenzymes will be an opportunity allowing the study of ultrafast processes that occur during catalysis and can only be observed with light-dependent enzymes such as electron and/or proton transfer, bond breaking ect. In fine, the goals of EXPERIMENTAL are to provide a better appreciation of the capabilities of enzymes and meet the demand for new and sustainable methods in organic synthesis by providing with the GMCox family a toolbox for the design of new light-driven reactions.

Conecta tu I+D

Entra hoy

¿Olvide mi contraseña?

Financiación

Empresas

CTIs/Universidades

Proyectos

Investigadores