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MICROCOSMS

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Exploring microbial community stability across mutational spectra

Interactions in which all partners benefit, known as mutualisms, underpin many vital ecosystem functions all across nature. Recent work by myself and others has shown that mutualisms can readily break down via a few independence-e... ver más

30/06/2025

UPM

181K€

Presupuesto del proyecto: 181K€

Líder del proyecto

UNIVERSIDAD POLITÉCNICA DE MADRID No se ha especificado una descripción o un objeto social para esta compañía.

Total investigadores 3948

Fecha límite participación Sin fecha límite de participación.

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Financiación concedida El organismo HORIZON EUROPE notifico la concesión del proyecto el día 2023-04-11

HORIZON-MSCA-2022-PF-01-01: MSCA Postdoctoral Fellowships 2022 Expected Outcome:

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2 Participantes

UPM

181.15K€ | Lider

INSERM

N.D. | Participante

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Duración del proyecto: 26 meses Fecha Inicio: 2023-04-11
Fecha Fin: 2025-06-30

Líder del proyecto

UNIVERSIDAD POLITÉCNICA DE MADRID No se ha especificado una descripción o un objeto social para esta compañía.

Total investigadores 3948

Presupuesto del proyecto 181K€

Fecha límite de participación Sin fecha límite de participación.

Descripción del proyecto Interactions in which all partners benefit, known as mutualisms, underpin many vital ecosystem functions all across nature. Recent work by myself and others has shown that mutualisms can readily break down via a few independence-enabling mutations, especially under environmental stress. Understanding the mechanisms that ensure mutualism stability is of increased importance for environmental, health, and societal problems. An unexplored question is the impact that large variations in mutational rates and spectra can have on in this process. Indeed, mutator strains, variants with highly elevated and biased mutation rates, readily take over microbial populations when there is ample adaptive opportunity, such as under environmental stress. These dramatic changes in spontaneous mutagenesis can have opposing effects on mutualism stability. On the one hand, they can lead to adaptive mutations appearing more rapidly, promoting partners survival and hence stabilising mutualisms. On the other hand, they may accelerate the acquisition of independence-enabling mutations, hence destabilising mutualism. With MICROCOSMS, I will address this open question by combining computer simulation with experimental evolution and genomics. I will experimentally evolve pairwise auxotrophic E. coli communities, genetically engineered to contain mutator variants that alter the mutational spectrum available. Pairwise communities will be assessed for mutualism stability when subject to both adaptive evolution, under strong antibiotic pressure, and non-adaptive evolution, where populations are subject to severe bottlenecking. These will be matched to simulations predicting the outcome of adaptive and non-adaptive evolution. By producing key insights into the stability of mutualisms under environmental stress, MICROCOSMS will form a knowledge base that will aide in protecting environmental and human-based ecosystems against disruptions.

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