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MpoxVax AFRIVAC

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Expanding a prospective clinical trial examining the immune response of partici...

Expanding a prospective clinical trial examining the immune response of participants receiving Modified Vaccinia Ankara vaccine to Africa. The current Mpox outbreak affecting the Democratic Republic of the Congo, ongoing since 2023, has resulted in more than 19,000 causes and over 1,000 deaths, with women accounting for more than half of those affected. The previous... see more

31/03/2027

unknown leader

1M€

Project Budget: 1M€

Project leader unknown leader

PARTICIPATION DEPralty Sin fecha límite de participación.

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Financing granted El organismo HORIZON EUROPE notifico la concesión del proyecto The day 2024-10-03

HORIZON-JU-GH-EDCTP3-2024-Mpox: Mobilisation of Emergency funding f... Expected Outcome:This topic aims at supporting activities that contribute to answering the most pres...

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Este proyecto no cuenta con búsquedas de partenariado abiertas en este momento.

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5 Participantes

UNIVERSITE CATHOLIQUE DE BUK...

THE UNIVERSITY COURT OF THE...

UGANDA NATIONAL HEALTH RESEA...

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Project duration: 29 months Date Start: 2024-10-03
End date: 2027-03-31

Project leader unknown leader

Project Budget 1M€

participation deadline Sin fecha límite de participación.

Project description The current Mpox outbreak affecting the Democratic Republic of the Congo, ongoing since 2023, has resulted in more than 19,000 causes and over 1,000 deaths, with women accounting for more than half of those affected. The previous global Mpox outbreak in 2022 was alleviated in part with use of preventive vaccination using modified vaccina Ankara (MVA) vaccine. However, whether this vaccine induces sufficient immune responses in women and those with immunosuppression, which is common in affected areas, and how long vaccine-induced immunity lasts is not well defined. Furthermore, outbreak responses within Africa are also limited by lack of robust diagnostics. The Mpox AFRIVAC Project will engage with key stakeholders and the community to address these knowledge gaps and capacity limitations by adapting a phase 4 clinical trial of pre-exposure vaccination against Mpox currently underway in Europe to African sites affected by the current outbreak. This will be accompanied by technology transfer to develop Mpox immune diagnostics and knowledge transfer to develop a regional vaccinee-focused Clinical Trials Unit. Together, these activities will address key strategic priorities within the region, address knowledge gaps and significantly contribute to regional capacity and public health response to bring an end to the Mpox outbreak.

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