Hola,
¿eres nuevo aquí?

Regístrate gratis y conecta tu empresa con financiación pública, partners y proyectos.

Tengo cuenta

Regístrate

Ver video

Expand Flow

Financiado

Cerrado

Expand Flow – Accessing new chemical space via a combined flash- and photochemic...

Expand Flow – Accessing new chemical space via a combined flash- and photochemical flow chemistry approach for the functionalisation and ring expansion of heterocycles With ever-increasing costs for the development of new drugs, the call for the development of more cost-effective and efficient methodologies to streamline the access to new drug candidates is imperative. To access new chemical spa... ver más

15/10/2025

UNIBA

173K€

Presupuesto del proyecto: 173K€

Líder del proyecto

UNIVERSITA DEGLI STUDI DI BARI ALDO MORO No se ha especificado una descripción o un objeto social para esta compañía.

TRL 4-5

Fecha límite participación Sin fecha límite de participación.

Financiación concedida El organismo HORIZON EUROPE notifico la concesión del proyecto el día 2023-03-30

HORIZON-MSCA-2022-PF-01-01: MSCA Postdoctoral Fellowships 2022 Expected Outcome:

I+D

Cerrada

0% 100% 100%

Características del participante

Este proyecto no cuenta con búsquedas de partenariado abiertas en este momento.

Información adicional privada

No hay información privada compartida para este proyecto. Habla con el coordinador.

1 Participantes

UNIBA

172.75K€ | Lider

Conecta tu I+D

¿Tienes un proyecto y buscas un partner? Gracias a nuestro motor inteligente podemos recomendarte los mejores socios y ponerte en contacto con ellos. Te lo explicamos en este video

Duración del proyecto: 30 meses Fecha Inicio: 2023-03-30
Fecha Fin: 2025-10-15

Líder del proyecto

UNIVERSITA DEGLI STUDI DI BARI ALDO MORO No se ha especificado una descripción o un objeto social para esta compañía.

TRL 4-5

Presupuesto del proyecto 173K€

Fecha límite de participación Sin fecha límite de participación.

Descripción del proyecto With ever-increasing costs for the development of new drugs, the call for the development of more cost-effective and efficient methodologies to streamline the access to new drug candidates is imperative. To access new chemical space, the ring-distortion strategy – late-stage modification of rings to a variety of different functionalized cyclic and acyclic motifs – has proven a particularly successful approach. Recently, numerous ring-expansion and functionalisation protocols to cyclopentanones, tetralones, γ-functionalized butanones from cyclobutanols have been developed using classical batch processes. Despite the advances, the translation to pharmaceutically relevant applications is still outstanding; mainly due to three factors: 1)The application of heterocycles in these protocols has been very limited or even impossible 2)The two-carbon ring expansion has only been successful on aryl-substituted analogues, yet not on alkene-substituted analogues & 3)Scale-up to practical quantities is often difficult due to the requirement for conditions difficult to realise using batch processing. Expand Flow presents a multidisciplinary project that lies in the intersection of flash chemistry and synthetic photo-catalysis with microfluidic engineering and computational chemistry for the development of a selective, sustainable and applicable methodology for the ring deconstruction and functionalisation of heterocycles. Ultimately, its applicability to the pharmaceutical industry will be proven by the total synthesis of THC and its hitherto unexplored heterocyclic analogues. Overall, this project will add a valuable tool to the synthetic chemist’s repertoire for the rapid, environmentally-friendly and cost-effective development of new drug candidates by the versatile functionalisation of various heterocycles. This innovative approach will have a high scientific, technological and societal impact, reinforcing the European competitiveness in the development of life-saving drugs.

Conecta tu I+D

Entra hoy

Forgot your password?

Financiación

Empresas

CTIs/Universidades

Proyectos

Investigadores