Expand Flow
Financiado
Expand Flow – Accessing new chemical space via a combined flash- and photochemic...
Expand Flow – Accessing new chemical space via a combined flash- and photochemical flow chemistry approach for the functionalisation and ring expansion of heterocycles
With ever-increasing costs for the development of new drugs, the call for the development of more cost-effective and efficient methodologies to streamline the access to new drug candidates is imperative. To access new chemical spa...
With ever-increasing costs for the development of new drugs, the call for the development of more cost-effective and efficient methodologies to streamline the access to new drug candidates is imperative. To access new chemical space, the ring-distortion strategy – late-stage modification of rings to a variety of different functionalized cyclic and acyclic motifs – has proven a particularly successful approach. Recently, numerous ring-expansion and functionalisation protocols to cyclopentanones, tetralones, γ-functionalized butanones from cyclobutanols have been developed using classical batch processes. Despite the advances, the translation to pharmaceutically relevant applications is still outstanding; mainly due to three factors:
1)The application of heterocycles in these protocols has been very limited or even impossible
2)The two-carbon ring expansion has only been successful on aryl-substituted analogues, yet not on alkene-substituted analogues &
3)Scale-up to practical quantities is often difficult due to the requirement for conditions difficult to realise using batch processing.
Expand Flow presents a multidisciplinary project that lies in the intersection of flash chemistry and synthetic photo-catalysis with microfluidic engineering and computational chemistry for the development of a selective, sustainable and applicable methodology for the ring deconstruction and functionalisation of heterocycles. Ultimately, its applicability to the pharmaceutical industry will be proven by the total synthesis of THC and its hitherto unexplored heterocyclic analogues.
Overall, this project will add a valuable tool to the synthetic chemist’s repertoire for the rapid, environmentally-friendly and cost-effective development of new drug candidates by the versatile functionalisation of various heterocycles. This innovative approach will have a high scientific, technological and societal impact, reinforcing the European competitiveness in the development of life-saving drugs.
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Duración del proyecto: 30 meses
Fecha Inicio: 2023-03-30
Fecha Fin: 2025-10-15
Fecha Fin: 2025-10-15
Línea de financiación: concedida
El organismo HORIZON EUROPE notifico la concesión del proyecto el día 2023-03-30
Línea de financiación objetivo
El proyecto se financió a través de la siguiente ayuda:
HORIZON-MSCA-2022-PF-01-01:
MSCA Postdoctoral Fellowships 2022
Cerrada
hace 2 años
Presupuesto
El presupuesto total del proyecto asciende a
173K€
Líder del proyecto
UNIVERSITA DEGLI STUDI DI BARI ALDO MORO
No se ha especificado una descripción o un objeto social para esta compañía.
Perfil tecnológico
TRL
4-5
Perfil tecnológico
TRL
4-5