Innovating Works

KaryodynEVO

Financiado
Evolutionary principles of nuclear dynamics and remodelling
Every eukaryote has a nucleus, a double lipid membrane-bound compartment that encapsulates the genome, but almost every nucleus is different - in shape, size, molecular composition, spatial organisation, and dynamics through the c... Every eukaryote has a nucleus, a double lipid membrane-bound compartment that encapsulates the genome, but almost every nucleus is different - in shape, size, molecular composition, spatial organisation, and dynamics through the cell cycle. Given its fundamental and universal functional roles in protecting the DNA and regulating the exchange of information and control machinery between genome and cytoplasm, one might ask the question: why are there so many ways to build and remodel a nucleus? Bringing together comparative genomics, phylogenetics, quantitative cell biology and experimental evolution in multiple microbial model systems drawn from across the eukaryotic tree, we set out to elucidate the genomic, biophysical and evolutionary factors that determine nuclear dynamics and remodelling - karyodynamics - within the context of cellular architecture and function. A comparative perspective driven by phylogenetics will enable us to separate universal principles of karyodynamics from species- and niche-specific adaptations, and dissect the reasons for the evolutionary and developmental plasticity that we observe experimentally. In turn, we can use these principles to infer, predict and validate phenotypes in novel and emerging model systems. Finally, a more comprehensive understanding of the mechanisms responsible for karyodynamic phenotypic diversity would allow us to reconstruct evolutionary trajectories all the way back to the origins of the nuclear compartment, a landmark event in the evolution of eukaryotes from an archaeal-bacterial symbiosis over 2 billion years ago. ver más
31/03/2028
EMBL
2M€
Perfil tecnológico estimado
Duración del proyecto: 64 meses Fecha Inicio: 2022-11-29
Fecha Fin: 2028-03-31

Línea de financiación: concedida

El organismo HORIZON EUROPE notifico la concesión del proyecto el día 2022-11-29
Línea de financiación objetivo El proyecto se financió a través de la siguiente ayuda:
ERC-2022-STG: ERC STARTING GRANTS
Cerrada hace 2 años
Presupuesto El presupuesto total del proyecto asciende a 2M€
Líder del proyecto
EUROPEAN MOLECULAR BIOLOGY LABORATORY No se ha especificado una descripción o un objeto social para esta compañía.