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EPYC

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Evolution of pro and eukaryotic commensals within the human gut

The EPYC project will characterize the evolution of long-term human associated eukaryotes and prokaryotes, using colonization patterns in 3 human generations. The gut microbiome is important for human health, supporting nutrition... see more

31/07/2026

QUADRAM INSTITUTE...

1M€

Project Budget: 1M€

Project leader

QUADRAM INSTITUTE BIOSCIENCE No se ha especificado una descripción o un objeto social para esta compañía.

TRL 4-5

PARTICIPATION DEPralty Sin fecha límite de participación.

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Financing granted El organismo H2020 notifico la concesión del proyecto The day 2021-01-20

ERC-2020-STG: ERC STARTING GRANTS Scope:Objectives

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Este proyecto no cuenta con búsquedas de partenariado abiertas en este momento.

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3 Participantes

QUADRAM INSTITUTE BIOSCIENCE

1.39M€ | Leader

SANTOS PROFESSIONAL SL EN LI...

EARLHAM INSTITUTE

108.30K€ | participant

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Project duration: 66 months Date Start: 2021-01-20
End date: 2026-07-31

Project leader

QUADRAM INSTITUTE BIOSCIENCE No se ha especificado una descripción o un objeto social para esta compañía.

TRL 4-5

Project Budget 1M€

participation deadline Sin fecha límite de participación.

Project description The EPYC project will characterize the evolution of long-term human associated eukaryotes and prokaryotes, using colonization patterns in 3 human generations. The gut microbiome is important for human health, supporting nutrition, pathogen defence and immune homeostasis, with more than 200 species inhabiting each human gut. In recent years metagenomics led to notable breakthroughs in describing this microbial diversity, yet 50-90% of species are typically present at too low abundance to be genome or strain resolved. Thus, most gut microbiome studies focused to date on dominant bacteria and very little is known of the highly diverse, yet low abundance, pro- and eukaryotes (elusive microbes). Importantly, elusive microbes are an inherent part of ecosystem successions persisting at different ages of the host. I propose that niche adaptation and persistence are key indicators of a taxa’s importance to the gut ecosystem and host health. I will determine which microbes persist for years within a human, or even a family for several generations. This should be reflected in microbial genetic adaption, also indicating which genes are likely important to successfully colonize the human gut. I hypothesize that low abundance pro- and eukaryotes are adapted to persist for multiple generations in the human host, indicating their importance, despite being largely ignored so far. To investigate this knowledge gap in EPYC, I will (O1) Enable high-precision metagenomics of elusive microbes (O2) Estimate pro- and eukaryotic strain persistence across three human generations (O3) Describe the microbial genetics of gastrointestinal persistence EPYC will develop the next-generation of high-resolution metagenomics of an extended taxonomic range, enabling me to research microbial evolution in the human gut.

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