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STOOL4TB

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Evaluating a new stool based qPCR for diagnosis of tuberculosis in children and...

Evaluating a new stool based qPCR for diagnosis of tuberculosis in children and people living with HIV The COVID-19 pandemic had a devastating impact on tuberculosis (TB) control. In 2020, the number of people newly diagnosed with TB decreased by 18% despite a rising global TB burden. Intensified efforts to improve TB case detectio... ver más

31/12/2025

FUNDACION PRIVADA...

348K€

Presupuesto del proyecto: 348K€

Líder del proyecto

FUNDACION PRIVADA INSTITUTO DE SALUD GLOBAL B... No se ha especificado una descripción o un objeto social para esta compañía.

TRL 4-5 | 27M€

Fecha límite participación Sin fecha límite de participación.

Ver 8 Participantes

Financiación concedida El organismo HORIZON EUROPE notifico la concesión del proyecto el día 2024-04-13

HORIZON-JU-GH-EDCTP3-2023-01-02: Funding to successfully finalise ED... ExpectedOutcome:Project results are expected to contribute to the following outcomes:

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8 Participantes

FUNDACION PRIVADA INSTITUTO...

140.78K€ | Lider

BAYLOR COLLEGE OF MEDICINE C...

AIGHD Foundation

9.20K€ | Participante

62.54K€ | Participante

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Duración del proyecto: 20 meses Fecha Inicio: 2024-04-13
Fecha Fin: 2025-12-31

Líder del proyecto

FUNDACION PRIVADA INSTITUTO DE SALUD GLOBAL B... No se ha especificado una descripción o un objeto social para esta compañía.

TRL 4-5 | 27M€

Presupuesto del proyecto 348K€

Fecha límite de participación Sin fecha límite de participación.

Descripción del proyecto The COVID-19 pandemic had a devastating impact on tuberculosis (TB) control. In 2020, the number of people newly diagnosed with TB decreased by 18% despite a rising global TB burden. Intensified efforts to improve TB case detection are critically needed, especially in populations in whom bacteriological confirmation is suboptimal, such as children and people living with HIV (PLHIV) who have also been disproportionately affected by the pandemic. The need for highly sensitive sputum-free diagnostic tools for TB has never been greater. STool4TB, an EDCTP-2 funded diagnostic trial, began its activities in 2020 shortly after the onset of the COVID-19 pandemic. The study aims to validate a novel quantitative PCR assay utilizing a stool homogenization and DNA isolation method that yields a highly sensitive and specific detection of Mycobacterium tuberculosis. STool4TB is implemented in high TB & HIV burden settings of Mozambique, Eswatini, and Uganda under the hypothesis that it will contribute to narrow the large TB case detection gap by improving TB lab-confirmation rates in children and PLHIV, while proving feasible and acceptable. New evidence suggests that this platform has a higher sensitivity when compared to sputum culture and Xpert Ultra and could have an additive lab-confirmation yield of up to 20%. STool4TB is also evaluating the qPCR platform as a treatment monitoring tool. This assay has the potential to be adapted to a POC diagnostic test which could be easily implemented in decentralized levels of care. Given the impact of the COVID-19 pandemic on TB notifications at the three participating sites and on several STool4TB core activities, we request additional funding to finalize recruitment of participants and achieve the target sample size, ensuring full execution of all project’s objectives. The observed upward trend in global TB burden makes the development of promising diagnostic tools, such as this novel stool-based qPCR, more important than ever.

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